| Literature DB >> 22386243 |
Heng Xu1, Haibo Zhang, Linbo Luan, Yan Xu, Chengyong Li, Yonghui Wang, Fangbin Han, Ting Yang, Feng Ren, Jia-Ning Xiang, John D Elliott, Yonggang Zhao, Taylor B Guo, Hongtao Lu, Wei Zhang, David Hirst, Matthew Lindon, Xichen Lin.
Abstract
High-throughput screening of GSK compound collection led to the discovery of a novel series of thiadiazole amides as potent and S1P(3)-sparing sphingosine-1-phosphate 1 (S1P(1)) receptor agonists. Synthesis, structure and activity relationship, selectivity, and some developability properties are described.Entities:
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Year: 2012 PMID： 22386243 DOI： 10.1016/j.bmcl.2012.02.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823