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Literature DB >> 22383808

Crystal structure of human enterovirus 71.

Pavel Plevka¹, Rushika Perera, Jane Cardosa, Richard J Kuhn, Michael G Rossmann.

Abstract

Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22383808 PMCID： PMC3448362 DOI： 10.1126/science.1218713

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

8 in total

Review 1. Picornavirus-receptor interactions.

Authors: Michael G Rossmann; Yongning He; Richard J Kuhn
Journal: Trends Microbiol Date: 2002-07 Impact factor: 17.079

2. Structure of a human common cold virus and functional relationship to other picornaviruses.

Authors: M G Rossmann; E Arnold; J W Erickson; E A Frankenberger; J P Griffith; H J Hecht; J E Johnson; G Kamer; M Luo; A G Mosser
Journal: Nature Date: 1985 Sep 12-18 Impact factor: 49.962

3. Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group.

Authors: L G Chan; U D Parashar; M S Lye; F G Ong; S R Zaki; J P Alexander; K K Ho; L L Han; M A Pallansch; A B Suleiman; M Jegathesan; L J Anderson
Journal: Clin Infect Dis Date: 2000-10-04 Impact factor: 9.079

4. Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.

Authors: B Sherry; A G Mosser; R J Colonno; R R Rueckert
Journal: J Virol Date: 1986-01 Impact factor: 5.103

5. Enterovirus 71 infections and neurologic disease--United States, 1977-1991.

Authors: J P Alexander; L Baden; M A Pallansch; L J Anderson
Journal: J Infect Dis Date: 1994-04 Impact factor: 5.226

6. Scavenger receptor B2 is a cellular receptor for enterovirus 71.

Authors: Seiya Yamayoshi; Yasuko Yamashita; Jifen Li; Nobutaka Hanagata; Takashi Minowa; Taro Takemura; Satoshi Koike
Journal: Nat Med Date: 2009-06-21 Impact factor: 53.440

7. Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1.

Authors: Kohei Miyamura; Yorihiro Nishimura; Masahiro Abo; Takaji Wakita; Hiroyuki Shimizu
Journal: J Gen Virol Date: 2010-10-13 Impact factor: 3.891

Review 8. Viral cell recognition and entry.

Authors: M G Rossmann
Journal: Protein Sci Date: 1994-10 Impact factor: 6.725

8 in total

101 in total

1. Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease.

Authors: Ke Lyu; Ya-Ling He; Hao-Yang Li; Rong Chen
Journal: J Virol Date: 2015-04-01 Impact factor: 5.103

2. Single Neutralizing Monoclonal Antibodies Targeting the VP1 GH Loop of Enterovirus 71 Inhibit both Virus Attachment and Internalization during Viral Entry.

Authors: Zhiqiang Ku; Xiaohua Ye; Jinping Shi; Xiaoli Wang; Qingwei Liu; Zhong Huang
Journal: J Virol Date: 2015-09-23 Impact factor: 5.103

3. Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids.

Authors: Chen Fan; Xiaohua Ye; Zhiqiang Ku; Liangliang Kong; Qingwei Liu; Cong Xu; Yao Cong; Zhong Huang
Journal: J Virol Date: 2017-03-29 Impact factor: 5.103

Crystal structure of human enterovirus 71.

Review 1. Picornavirus-receptor interactions.

2. Structure of a human common cold virus and functional relationship to other picornaviruses.

3. Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group.

4. Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.

5. Enterovirus 71 infections and neurologic disease--United States, 1977-1991.

6. Scavenger receptor B2 is a cellular receptor for enterovirus 71.

7. Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1.

Review 8. Viral cell recognition and entry.

1. Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease.

2. Single Neutralizing Monoclonal Antibodies Targeting the VP1 GH Loop of Enterovirus 71 Inhibit both Virus Attachment and Internalization during Viral Entry.

3. Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids.

4. Human enterovirus 71 uncoating captured at atomic resolution.

Review 5. Is a multivalent hand, foot, and mouth disease vaccine feasible?

6. Enhancement of tomogram interpretability using the locked self-rotation function.

7. Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.

8. Crystal structures of enterovirus 71 (EV71) recombinant virus particles provide insights into vaccine design.

Review 9. Progress on the research and development of human enterovirus 71 (EV71) vaccines.

10. MOPS and coxsackievirus B3 stability.