BACKGROUND: Antimicrobial stewardship programs (ASP) have been implemented to promote rational use of antimicrobial drugs. Multidisciplinary teams are needed to form effective committees. OBJECTIVE: Assess the impact of ASP, with and without the presence of a pharmacist, in a cardiology hospital in Brazil. METHODS: The program started with an infectious disease (ID) physician, and after 22 months, a pharmacist started to work in the ASP team. We present data related to: stage 1-before the program implementation; stage 2-with the ID physician; and stage 3 with the inclusion of a pharmacist. Analysis was made by segmented regression of time series. RESULTS: After the start of ASP there was a significant reduction of consumption of all antimicrobials. The pharmacist contributed to the significant reduction in consumption of fluoroquinolones, clindamycin and ampicillin/sulbactam and in increase in total cephalosporins use in stage 3. Adherence rate to the ASP team recommendations was 64.1%. There was a significant reduction of 69% in hospital antibiotics costs. CONCLUSION: A non-expensive ASP in a limited resource country resulted in reductions in antimicrobial consumption and costs. The multidisciplinary team contributed to maximize the impact of interventions.
BACKGROUND: Antimicrobial stewardship programs (ASP) have been implemented to promote rational use of antimicrobial drugs. Multidisciplinary teams are needed to form effective committees. OBJECTIVE: Assess the impact of ASP, with and without the presence of a pharmacist, in a cardiology hospital in Brazil. METHODS: The program started with an infectious disease (ID) physician, and after 22 months, a pharmacist started to work in the ASP team. We present data related to: stage 1-before the program implementation; stage 2-with the ID physician; and stage 3 with the inclusion of a pharmacist. Analysis was made by segmented regression of time series. RESULTS: After the start of ASP there was a significant reduction of consumption of all antimicrobials. The pharmacist contributed to the significant reduction in consumption of fluoroquinolones, clindamycin and ampicillin/sulbactam and in increase in total cephalosporins use in stage 3. Adherence rate to the ASP team recommendations was 64.1%. There was a significant reduction of 69% in hospital antibiotics costs. CONCLUSION: A non-expensive ASP in a limited resource country resulted in reductions in antimicrobial consumption and costs. The multidisciplinary team contributed to maximize the impact of interventions.
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Authors: S Natsch; Y A Hekster; R de Jong; E R Heerdink; R M Herings; J W van der Meer Journal: Eur J Clin Microbiol Infect Dis Date: 1998-01 Impact factor: 3.267
Authors: R S Evans; J A Olson; E Stenehjem; W R Buckel; E A Thorell; S Howe; X Wu; P S Jones; J F Lloyd Journal: Appl Clin Inform Date: 2015-03-03 Impact factor: 2.342
Authors: Peter Davey; Charis A Marwick; Claire L Scott; Esmita Charani; Kirsty McNeil; Erwin Brown; Ian M Gould; Craig R Ramsay; Susan Michie Journal: Cochrane Database Syst Rev Date: 2017-02-09
Authors: Thaciana Dos S Alcântara; Thelma Onozato; Fernando de C Araújo Neto; Aline S Dosea; Luiza C Cunha; Dyego C S A de Araújo; Déborah Pimentel; Divaldo P Lyra Junior Journal: BMC Health Serv Res Date: 2018-04-04 Impact factor: 2.655