| Literature DB >> 22382639 |
Amir Y Shaikh1, Jeffrey A Shih.
Abstract
Anthracycline-based chemotherapeutics have long been recognized as effective agents for treating a wide range of malignancies. However, their use is not without significant adverse cardiotoxic side effects. Strategies for prevention involve limiting free-radical production and subsequent cardiac myocyte damage. Dexrazoxane remains the most widely studied cardioprotective medication. Alternative agents may reduce cardiotoxicity but may still cause significant cardiovascular problems. The role of β-blockers and angiotensin-converting enzyme inhibitors in the treatment of heart failure is well proven. The role of these medications in the prevention and treatment of chemotherapy-induced cardiotoxicity is not well established.Entities:
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Year: 2012 PMID: 22382639 DOI: 10.1007/s11897-012-0083-y
Source DB: PubMed Journal: Curr Heart Fail Rep ISSN: 1546-9530