Literature DB >> 22382639

Chemotherapy-induced cardiotoxicity.

Amir Y Shaikh1, Jeffrey A Shih.   

Abstract

Anthracycline-based chemotherapeutics have long been recognized as effective agents for treating a wide range of malignancies. However, their use is not without significant adverse cardiotoxic side effects. Strategies for prevention involve limiting free-radical production and subsequent cardiac myocyte damage. Dexrazoxane remains the most widely studied cardioprotective medication. Alternative agents may reduce cardiotoxicity but may still cause significant cardiovascular problems. The role of β-blockers and angiotensin-converting enzyme inhibitors in the treatment of heart failure is well proven. The role of these medications in the prevention and treatment of chemotherapy-induced cardiotoxicity is not well established.

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Year:  2012        PMID: 22382639     DOI: 10.1007/s11897-012-0083-y

Source DB:  PubMed          Journal:  Curr Heart Fail Rep        ISSN: 1546-9530


  64 in total

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6.  Gingerol-derivatives: emerging new therapy against human drug-resistant MCF-7.

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Review 7.  Anthracycline-Induced Cardiotoxicity: Causes, Mechanisms, and Prevention.

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