A Sevelsted1, H Bisgaard. 1. Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Gentofte, Copenhagen, Denmark.
Abstract
BACKGROUND: We hypothesized that anthropometrics in the newborn is associated with development of asthma later in life. METHODS: The study included a prospective, longitudinal clinical study of a birth cohort of 411 Danish neonates born at term of mothers with a history of asthma. The primary endpoint was physician-diagnosed asthma at age 7 years. Allergic sensitization and atopic dermatitis (AD) were also investigated. Infant size was measured at the research clinic on four occasions during the first year of life. Risk for asthma, AD, and allergic sensitization at age 6-7 were estimated from logistic regression. Time to first asthma and AD were investigated by Cox regression. Multivariate models were adjusted for gender, gestational age, and mothers smoking during pregnancy. RESULTS: Neonatal weight, length, body mass index and head circumference (z-score) were all significantly associated with asthma at age 7. Adjusted odds ratio for asthma by estimated birth weight z-score: 1.87 [1.23-2.84]; P = 0.004. Adjusted HR for onset of asthma by neonatal weight z-score: 1.46 [1.08-1.96]; P = 0.013. Neonatal size did not associate with AD or allergic sensitization. CONCLUSIONS: Increased neonatal size was significantly associated with asthma at age 7 but not AD or allergic sensitization in at-risk children born at term. The findings suggest some common prenatal mechanisms linking body size and asthma.
BACKGROUND: We hypothesized that anthropometrics in the newborn is associated with development of asthma later in life. METHODS: The study included a prospective, longitudinal clinical study of a birth cohort of 411 Danish neonates born at term of mothers with a history of asthma. The primary endpoint was physician-diagnosed asthma at age 7 years. Allergic sensitization and atopic dermatitis (AD) were also investigated. Infant size was measured at the research clinic on four occasions during the first year of life. Risk for asthma, AD, and allergic sensitization at age 6-7 were estimated from logistic regression. Time to first asthma and AD were investigated by Cox regression. Multivariate models were adjusted for gender, gestational age, and mothers smoking during pregnancy. RESULTS: Neonatal weight, length, body mass index and head circumference (z-score) were all significantly associated with asthma at age 7. Adjusted odds ratio for asthma by estimated birth weight z-score: 1.87 [1.23-2.84]; P = 0.004. Adjusted HR for onset of asthma by neonatal weight z-score: 1.46 [1.08-1.96]; P = 0.013. Neonatal size did not associate with AD or allergic sensitization. CONCLUSIONS: Increased neonatal size was significantly associated with asthma at age 7 but not AD or allergic sensitization in at-risk children born at term. The findings suggest some common prenatal mechanisms linking body size and asthma.
Authors: Christine Cole Johnson; Edward L Peterson; Christine L M Joseph; Dennis R Ownby; Naomi Breslau Journal: J Asthma Date: 2015-09-16 Impact factor: 2.515
Authors: Maria C Magnus; Hein Stigum; Siri E Håberg; Per Nafstad; Stephanie J London; Wenche Nystad Journal: PLoS One Date: 2015-01-30 Impact factor: 3.240
Authors: R V Fenger; C Vidal; A Gonzalez-Quintela; L L N Husemoen; T Skaaby; M Aadahl; A Linneberg Journal: BMJ Open Date: 2014-02-28 Impact factor: 2.692
Authors: Agnes M M Sonnenschein-van der Voort; Lidia R Arends; Johan C de Jongste; Isabella Annesi-Maesano; S Hasan Arshad; Henrique Barros; Mikel Basterrechea; Hans Bisgaard; Leda Chatzi; Eva Corpeleijn; Sofia Correia; Leone C Craig; Graham Devereux; Cristian Dogaru; Miroslav Dostal; Karel Duchen; Merete Eggesbø; C Kors van der Ent; Maria P Fantini; Francesco Forastiere; Urs Frey; Ulrike Gehring; Davide Gori; Anne C van der Gugten; Wojciech Hanke; A John Henderson; Barbara Heude; Carmen Iñiguez; Hazel M Inskip; Thomas Keil; Cecily C Kelleher; Manolis Kogevinas; Eskil Kreiner-Møller; Claudia E Kuehni; Leanne K Küpers; Kinga Lancz; Pernille S Larsen; Susanne Lau; Johnny Ludvigsson; Monique Mommers; Anne-Marie Nybo Andersen; Lubica Palkovicova; Katharine C Pike; Costanza Pizzi; Kinga Polanska; Daniela Porta; Lorenzo Richiardi; Graham Roberts; Anne Schmidt; Radim J Sram; Jordi Sunyer; Carel Thijs; Maties Torrent; Karien Viljoen; Alet H Wijga; Martine Vrijheid; Vincent W V Jaddoe; Liesbeth Duijts Journal: J Allergy Clin Immunol Date: 2014-02-12 Impact factor: 10.793