| Literature DB >> 22377515 |
Nyung Kim1, Mi-Jin Sohn, Chang-Jin Kim, Ho Jeong Kwon, Won-Gon Kim.
Abstract
New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC(50) of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22377515 DOI： 10.1016/j.bmcl.2012.02.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823