Joong Ho Ahn1, Myung Joo Shim. 1. Department of Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. meniere@amc.seoul.kr
Abstract
OBJECTIVE: To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate-carboxymethylcellulose (HA-CMC) in reducing postoperative painafter temporalis fascia harvest during tympanomastoid surgery. MATERIALS AND METHODS:Between January and December 2009, 27 patients underwent tympanoplasty and open cavity mastoidectomy involving the harvesting of temporalis fasciae (more than 3×4cm). At the end of surgery, patients were injected with 1.5g HA-CMC or normal saline around the fascia harvest area. Beginning immediately postoperatively and for 2 months after surgery, patients scored their pain in the temporal area on a visual analogue scale (VAS). RESULTS: There were no significant postoperative complications, such as bleeding or hematoma, in either control group. VAS scores of both groups decreased over time and were negligible after 2 months. VAS scores of the HA-CMC and control groups differed significantly (p<0.001 by repeated measures ANOVA for all VAS scores). CONCLUSION:HA-CMC can decrease immediate postoperative pain arising from tissue adhesion and inflammation, thus reducing postoperative mastication pain.
RCT Entities:
OBJECTIVE: To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate-carboxymethylcellulose (HA-CMC) in reducing postoperative pain after temporalis fascia harvest during tympanomastoid surgery. MATERIALS AND METHODS: Between January and December 2009, 27 patients underwent tympanoplasty and open cavity mastoidectomy involving the harvesting of temporalis fasciae (more than 3×4cm). At the end of surgery, patients were injected with 1.5g HA-CMC or normal saline around the fascia harvest area. Beginning immediately postoperatively and for 2 months after surgery, patients scored their pain in the temporal area on a visual analogue scale (VAS). RESULTS: There were no significant postoperative complications, such as bleeding or hematoma, in either control group. VAS scores of both groups decreased over time and were negligible after 2 months. VAS scores of the HA-CMC and control groups differed significantly (p<0.001 by repeated measures ANOVA for all VAS scores). CONCLUSION:HA-CMC can decrease immediate postoperative pain arising from tissue adhesion and inflammation, thus reducing postoperative mastication pain.