| Literature DB >> 22375879 |
Wei-Huan Huang1, Guang-Xiong Zhou, Guo-Cai Wang, Hau-Yin Chung, Wen-Cai Ye, Yao-Lan Li.
Abstract
A new biflavonoid, 4'-methoxydaphnodorin E, was isolated from the antiviral fraction of Wikstroemia indica against respiratory syncytial virus (RSV). Its structure was determined on the basis of extensive spectroscopic data including HR-ESI-MS and 2D NMR. The biflavonoid was tested for its in vitro anti-RSV activity with cytopathic effect (CPE) reduction assay, and displayed potent effect with 50% inhibitory concentration (IC₅₀) value of 2.8 μM and selective index (SI) value of 5.4.Entities:
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Year: 2012 PMID： 22375879 DOI： 10.1080/10286020.2011.653963
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569