Literature DB >> 22375622

DNA conjugated SWCNTs enter endothelial cells via Rac1 mediated macropinocytosis.

Santanu Bhattacharya1, Daniel Roxbury, Xun Gong, Debabrata Mukhopadhyay, Anand Jagota.   

Abstract

Several applications of single-walled carbon nanotubes (SWCNT) as nanovectors in biological systems have been reported, and several molecular pathways of cellular entry have been proposed. We employed transmission electron microscopy, confocal fluorescent microscopy, and UV-vis spectroscopic analysis to confirm the internalization of DNA-SWCNT in human umbilical vein endothelial cells. Additionally, by using pharmacological inhibitors as well as genetic approaches, we have found that SWCNT is endocytosed through Rac1- GTPase mediated macropinocytosis in normal endothelial cells.
© 2012 American Chemical Society

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Year:  2012        PMID： 22375622      PMCID： PMC3324635          DOI： 10.1021/nl204058u

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  46 in total

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Journal:  Nat Nanotechnol       Date:  2008-12-14       Impact factor: 39.213

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Journal:  Nat Nanotechnol       Date:  2007-01-28       Impact factor: 39.213

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  18 in total

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3.  DNA-SWCNT Biosensors Allow Real-Time Monitoring of Therapeutic Responses in Pancreatic Ductal Adenocarcinoma.

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5.  Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation.

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10.  Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging.

Authors:  Daniel Roxbury; Prakrit V Jena; Ryan M Williams; Balázs Enyedi; Philipp Niethammer; Stéphane Marcet; Marc Verhaegen; Sébastien Blais-Ouellette; Daniel A Heller
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