OBJECTIVE: To evaluate the effect of serum albumin on prognosis and the power of albumin adding information to NT-proBNP in a Chinese cohort of heart failure. DESIGN AND METHODS: 385 consecutive patients (male vs. female: 292 vs. 93; mean age: 54.89±14.41years; NYHA classes II-V) admitted for heart failure exacerbation with LVEF≤45% were enrolled, and biochemical data was measured at baseline. The endpoint was defined as cardiac death or rehospitalization for aggravated heart failure. Follow-up period was 25±7months. RESULTS: Multivariate analysis in a Cox proportional hazard model revealed serum albumin was an independent predictor for adverse prognosis (HR 0.96,CI 0.94-0.99, P=0.02), and the patients with higher NT-proBNP and lower albumin than median had the highest risk for cardiac events (HR 2.89, CI 1.90-4.40, P<0.01). CONCLUSION: Serum albumin is a significant prognosis indicator for heart failure and it adds important information to NT-proBNP.
OBJECTIVE: To evaluate the effect of serum albumin on prognosis and the power of albumin adding information to NT-proBNP in a Chinese cohort of heart failure. DESIGN AND METHODS: 385 consecutive patients (male vs. female: 292 vs. 93; mean age: 54.89±14.41years; NYHA classes II-V) admitted for heart failure exacerbation with LVEF≤45% were enrolled, and biochemical data was measured at baseline. The endpoint was defined as cardiac death or rehospitalization for aggravated heart failure. Follow-up period was 25±7months. RESULTS: Multivariate analysis in a Cox proportional hazard model revealed serum albumin was an independent predictor for adverse prognosis (HR 0.96,CI 0.94-0.99, P=0.02), and the patients with higher NT-proBNP and lower albumin than median had the highest risk for cardiac events (HR 2.89, CI 1.90-4.40, P<0.01). CONCLUSION:Serum albumin is a significant prognosis indicator for heart failure and it adds important information to NT-proBNP.
Authors: Mahmoud El Iskandarani; Bara El Kurdi; Ghulam Murtaza; Timir K Paul; Marwan M Refaat Journal: Medicine (Baltimore) Date: 2021-03-12 Impact factor: 1.817