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Literature DB >> 22373586

A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells.

Jing-Jing Zhang¹, Raymond Wai-Yin Sun, Chi-Ming Che.

Abstract

The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations. This journal is © The Royal Society of Chemistry 2012

Entities: Chemical Disease

Mesh：

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Year: 2012 PMID： 22373586 DOI： 10.1039/c2cc00029f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

6 in total

1. New minor groove covering DNA binding mode of dinuclear Pt(II) complexes with various pyridine-linked bridging ligands and dual anticancer-antiangiogenic activities.

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Journal: J Biol Inorg Chem Date: 2020-03-11 Impact factor: 3.358

Review 2. Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies.

Authors: Mehvash Zaki; Suboot Hairat; Elham S Aazam
Journal: RSC Adv Date: 2019-01-24 Impact factor: 4.036

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

Authors: Benoît Bertrand; Julio Fernandez-Cestau; Jesus Angulo; Marco M D Cominetti; Zoë A E Waller; Mark Searcey; Maria A O'Connell; Manfred Bochmann
Journal: Inorg Chem Date: 2017-04-25 Impact factor: 5.165

A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells.

1. New minor groove covering DNA binding mode of dinuclear Pt(II) complexes with various pyridine-linked bridging ligands and dual anticancer-antiangiogenic activities.

Review 2. Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies.

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

Review 4. Cytoplasmic vacuolization in cell death and survival.

Review 5. Biological Properties of Transition Metal Complexes with Metformin and Its Analogues.

6. Water-Soluble Gold(III)-Metformin Complex Alters Mitochondrial Bioenergetics in Breast Cancer Cells.

A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells.

1. New minor groove covering DNA binding mode of dinuclear Pt(II) complexes with various pyridine-linked bridging ligands and dual anticancer-antiangiogenic activities.

Review 2. Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies.

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

Review 4. Cytoplasmic vacuolization in cell death and survival.

Review 5. Biological Properties of Transition Metal Complexes with Metformin and Its Analogues.

6. Water-Soluble Gold(III)-Metformin Complex Alters Mitochondrial Bioenergetics in Breast Cancer Cells.

3. Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.