Literature DB >> 223731

Potentiation of the effects of GABA by pentobarbitone.

R H Evans.   

Abstract

Pentobarbitone (50 microM) has been shown to potentiate GABA-induced responses in rat isolated superior cervical ganglia and in dorsal or ventral root fibres of immature rat isolated spinal cords. Measurements of dose ratios for the antagonism of GABA-induced responses of dorsal root fibres by bicuculline showed that pentobarbitone (50 microM) did not significantly alter this antagonism. This result indicates that the antagonism of GABA by bucuculline at dorsal root fibres is not reversed by pentobarbitone. Ventral root responses to GABA (but not glycine) were also potentiated by pentobarbitone (+/-)-Nipecotic acid (300 microM) potentiated responses to GABA much more than those to 3-aminopropane-sulphonic acid.

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Year:  1979        PMID： 223731     DOI： 10.1016/0006-8993(79)90736-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  23 in total

1.  Kinetic and pharmacological properties of the GABA-induced chloride current in Aplysia neurones: a 'concentration clamp' study.

Authors:  Y Ikemoto; N Akaike; H Kijima
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

2.  Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes.

Authors:  J H Skerritt; G A Johnston; T Katsikas; J Tabar; G M Nicholson; P R Andrews
Journal:  Neurochem Res       Date:  1983-10       Impact factor: 3.996

Review 3.  Mechanisms of anaesthesia: a review.

Authors:  S H Roth
Journal:  Can Anaesth Soc J       Date:  1980-09

4.  Direct excitant action of convulsant barbiturates.

Authors:  P R Andrews; R H Evans; G A Johnston; M Willow
Journal:  Experientia       Date:  1981-02-15

5.  Effect of barbiturates on the GABA receptor of cat primary afferent neurones.

Authors:  H Higashi; S Nishi
Journal:  J Physiol       Date:  1982-11       Impact factor: 5.182

6.  Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination.

Authors:  S A Thompson; P J Whiting; K A Wafford
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

7.  gamma-Aminobutyric acid agonists: an in vitro comparison between depression of spinal synaptic activity and depolarization of spinal root fibres in the rat.

Authors:  R D Allan; R H Evans; G A Johnston
Journal:  Br J Pharmacol       Date:  1980-12       Impact factor: 8.739

8.  Comparison of the effects of bicuculline and strychnine on brain stem auditory evoked potentials in the cat.

Authors:  M R Martin; L P Penix
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

9.  Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study.

Authors:  Elke Ziegler; M Bodusch; Y Song; K Jahn; H Wolfes; S Steinlechner; R Dengler; J Bufler; K Krampfl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-08-25       Impact factor: 3.000

10.  The effects of benzodiazepine agonists, inverse agonists and Ro 15-1788 on the responses of the superior cervical ganglion to GABA in vitro.

Authors:  H J Little
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739
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