Ali Ghazavi1, Saeed Kianbakht, Keyvan Ghasami, Ghasem Mosayebi. 1. Tuberculosis and Pediatric Infectious Research Center (TPIRC), Department of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract
BACKGROUND: The purpose of this study was to evaluate the levels of zinc (Zn) and copper (Cu) in the serum of Iranian patients with multiple sclerosis (MS). METHODS: The serum levels of zinc (Zn) and copper (Cu) were measured in sixty Iranian patients with MS and compared with sixty age-, gender- and socioeconomic status-matched healthy subjects without any neurological disorders as controls from the same geographical area. RESULTS: Significantly lower serum Zn and higher serum Cu levels were found in the MS patients compared with the controls (p < 0.0001 and p = 0.002, respectively). The serum Zn level of the secondary-progressive MS patients was significantly lower compared with the relapsing-remitting MS patients (p = 0.009). There was no significant difference between the serum Cu levels of the two subgroup of MS patients (p = 0.42). CONCLUSIONS: The results suggest significant deviations of the Iranian MS patients' serum Zn and Cu levels from the norm.
BACKGROUND: The purpose of this study was to evaluate the levels of zinc (Zn) and copper (Cu) in the serum of Iranian patients with multiple sclerosis (MS). METHODS: The serum levels of zinc (Zn) and copper (Cu) were measured in sixty Iranian patients with MS and compared with sixty age-, gender- and socioeconomic status-matched healthy subjects without any neurological disorders as controls from the same geographical area. RESULTS: Significantly lower serum Zn and higher serum Cu levels were found in the MSpatients compared with the controls (p < 0.0001 and p = 0.002, respectively). The serum Zn level of the secondary-progressive MSpatients was significantly lower compared with the relapsing-remitting MSpatients (p = 0.009). There was no significant difference between the serum Cu levels of the two subgroup of MSpatients (p = 0.42). CONCLUSIONS: The results suggest significant deviations of the Iranian MSpatients' serum Zn and Cu levels from the norm.
Authors: Pedro Iñarrea; Raquel Alarcia; María A Alava; José L Capablo; Alvaro Casanova; Cristina Iñiguez; María Iturralde; Pilar Larrodé; Jesús Martín; Enrique Mostacero; José R Ara Journal: Mol Neurobiol Date: 2013-06-13 Impact factor: 5.590