| Literature DB >> 22370847 |
Paulo Antas1, Steven Holland, Timothy Sterling.
Abstract
Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.Entities:
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Year: 2012 PMID： 22370847 PMCID： PMC3981535 DOI： 10.1590/s0037-86822012000100029
Source DB: PubMed Journal: Rev Soc Bras Med Trop ISSN： 0037-8682 Impact factor: 1.581