Literature DB >> 22370774

Multi-targeted hybrids based on HDAC inhibitors for anti-cancer drug discovery.

Seung-Yong Seo1.   

Abstract

Multi-targeted hybrids combine two drugs in a single molecule to have greater medicinal effects than its individual components. Recently, a number of anti-cancer drug candidates such as CUDC-101 (Curis) have been designed based on linking properly two selected pharmacophores endowed with activity against different therapeutic targets.

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Year:  2012        PMID： 22370774     DOI： 10.1007/s12272-012-0221-9

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  6 in total

Review 1.  Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids.

Authors:  Harbinder Singh; Jatinder Vir Singh; Kavita Bhagat; Harmandeep Kaur Gulati; Mohit Sanduja; Nitish Kumar; Nihar Kinarivala; Sahil Sharma
Journal:  Bioorg Med Chem       Date:  2019-06-22       Impact factor: 3.641

2.  Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.

Authors:  Berkley E Gryder; Michael K Rood; Kenyetta A Johnson; Vishal Patil; Eric D Raftery; Li-Pan D Yao; Marcie Rice; Bahareh Azizi; Donald F Doyle; Adegboyega K Oyelere
Journal:  J Med Chem       Date:  2013-07-03       Impact factor: 7.446

3.  Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group.

Authors:  Ji Hyun Kim; Khan Hashim Ali; Yong Jin Oh; Young Ho Seo
Journal:  Medicine (Baltimore)       Date:  2022-04-29       Impact factor: 1.817

4.  Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation.

Authors:  Duong T Anh; Pham-The Hai; Le D Huy; Hoang B Ngoc; Trinh T M Ngoc; Do T M Dung; Eun J Park; In K Song; Jong S Kang; Joo-Hee Kwon; Truong T Tung; Sang-Bae Han; Nguyen-Hai Nam
Journal:  ACS Omega       Date:  2021-02-08

5.  Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors.

Authors:  Lanlan Zang; Shukkoor M Kondengaden; Qing Zhang; Xiaobo Li; Dilep K Sigalapalli; Shameer M Kondengadan; Kenneth Huang; Keqin Kathy Li; Shanshan Li; Zhongying Xiao; Liuqing Wen; Hailiang Zhu; Bathini N Babu; Lijuan Wang; Fengyuan Che; Peng George Wang
Journal:  Oncotarget       Date:  2017-06-28

6.  Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors.

Authors:  Regina Martínez; Bruno Di Geronimo; Miryam Pastor; José María Zapico; Claire Coderch; Rostyslav Panchuk; Nadia Skorokhyd; Maciej Maslyk; Ana Ramos; Beatriz de Pascual-Teresa
Journal:  Molecules       Date:  2020-03-25       Impact factor: 4.411
  6 in total

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