X-L Li1, J-H Xu. 1. Department of Nutrition and Food Hygiene, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China. lixinli@suda.edu.cn
Abstract
BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms implicated in the cancer development, but the published studies had yielded inconsistent results. METHODS: Pubmed was searched for all published case-control studies about MTHFR polymorphisms and prostate cancer risk. RESULTS: In all, 13 studies including 5872 cases and 6255 controls described C677T genotypes, among which 9 articles, containing 2847 cases and 3657 controls described A1298C genotypes, were involved in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between MTHFR polymorphisms and prostate cancer risk, heterogeneity, publication bias and sensitivity were also calculated. Overall, meta-analysis indicated that the 677T allele was more likely to exert protective effect on prostate cancer risk (random-effects pooled OR, 0.78 (0.64-0.96); P=0.016 (P=0.033 for heterogeneity studies)) in a recessive genetic model, no associations were found in other genetic models or in comparing a/a versus A/A homozygous. Neither did we find any difference in effects on high or low aggressive prostate cancer. No evidence of an association of MTHFR A1298C polymorphism with prostate cancer was found. CONCLUSIONS: C677T of the MTHFR gene may provide protective effects on susceptibility to prostate cancer risk.
BACKGROUND:5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms implicated in the cancer development, but the published studies had yielded inconsistent results. METHODS: Pubmed was searched for all published case-control studies about MTHFR polymorphisms and prostate cancer risk. RESULTS: In all, 13 studies including 5872 cases and 6255 controls described C677T genotypes, among which 9 articles, containing 2847 cases and 3657 controls described A1298C genotypes, were involved in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between MTHFR polymorphisms and prostate cancer risk, heterogeneity, publication bias and sensitivity were also calculated. Overall, meta-analysis indicated that the 677T allele was more likely to exert protective effect on prostate cancer risk (random-effects pooled OR, 0.78 (0.64-0.96); P=0.016 (P=0.033 for heterogeneity studies)) in a recessive genetic model, no associations were found in other genetic models or in comparing a/a versus A/A homozygous. Neither did we find any difference in effects on high or low aggressive prostate cancer. No evidence of an association of MTHFRA1298C polymorphism with prostate cancer was found. CONCLUSIONS:C677T of the MTHFR gene may provide protective effects on susceptibility to prostate cancer risk.
Authors: Anca Botezatu; Demetra Socolov; Iulia V Iancu; Irina Huica; Adriana Plesa; Carmen Ungureanu; Gabriela Anton Journal: J Cell Mol Med Date: 2013-02-28 Impact factor: 5.310