Literature DB >> 22370269

Discovery of P2X3 selective antagonists for the treatment of chronic pain.

Louis-David Cantin1, Malken Bayrakdarian, Christophe Buon, Eric Grazzini, Yun-Jin Hu, Jean Labrecque, Carmen Leung, Xuehong Luo, Giovanni Martino, Michel Paré, Kemal Payza, Nirvana Popovic, Denis Projean, V Santhakumar, Christopher Walpole, Xiao Hong Yu, Mirosław J Tomaszewski.   

Abstract

Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22370269     DOI： 10.1016/j.bmcl.2012.01.124

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  P2X receptors as drug targets.

Authors:  R Alan North; Michael F Jarvis
Journal:  Mol Pharmacol       Date:  2012-12-19       Impact factor: 4.436

Review 2.  Purinergic Signalling: Therapeutic Developments.

Authors:  Geoffrey Burnstock
Journal:  Front Pharmacol       Date:  2017-09-25       Impact factor: 5.810

3.  Pyrid-2-yl and 2-CyanoPhenyl fused heterocyclic compounds as human P2X3 inhibitors: a combined approach based on homology modelling, docking and QSAR analysis.

Authors:  Sridhara Janardhan; Subhendu Seth; Vellarkad N Viswanadhan
Journal:  Mol Divers       Date:  2013-10-24       Impact factor: 2.943

Review 4.  Nanomedicines for Endometriosis: Lessons Learned from Cancer Research.

Authors:  Abraham S Moses; Ananiya A Demessie; Olena Taratula; Tetiana Korzun; Ov D Slayden; Oleh Taratula
Journal:  Small       Date:  2021-01-25       Impact factor: 13.281

5.  Effects of resveratrol in the signaling of neuropathic pain involving P2X3 in the dorsal root ganglion of rats.

Authors:  Jinhui Guo; Chaowei Wang; Xiaolu Niu; Fang Zhou; Huiling Li; Weifang Gao
Journal:  Acta Neurol Belg       Date:  2019-04-15       Impact factor: 2.396

6.  Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.

Authors:  Paolo Vincetti; Suzanne J F Kaptein; Gabriele Costantino; Johan Neyts; Marco Radi
Journal:  ACS Med Chem Lett       Date:  2019-01-23       Impact factor: 4.345

7.  Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain.

Authors:  Ming Yuan; Shaojie Ding; Tingting Meng; Binbin Lu; Shihong Shao; Xinmei Zhang; Hong Yuan; Fuqiang Hu
Journal:  Int J Nanomedicine       Date:  2017-11-09

8.  Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers.

Authors:  Adam J Davenport; Ioana Neagoe; Nico Bräuer; Markus Koch; Andrea Rotgeri; Jens Nagel; Alexis Laux-Biehlmann; Frederic Machet; Anne-Marie Coelho; Susan Boyce; Nikisha Carty; Mark J Gemkow; Stephen D Hess; Thomas M Zollner; Oliver M Fischer
Journal:  Sci Rep       Date:  2021-10-06       Impact factor: 4.379

Review 9.  P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain.

Authors:  Jeffrey L Krajewski
Journal:  Neurotherapeutics       Date:  2020-10-02       Impact factor: 6.088

10.  P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.

Authors:  Shaojie Ding; Libo Zhu; Yonghong Tian; Tianhong Zhu; Xiufeng Huang; Xinmei Zhang
Journal:  PLoS One       Date:  2017-09-12       Impact factor: 3.240
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.