Literature DB >> 22368518

Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?

Lauren Walker, Graeme J Sills.   

Abstract

Emerging data from experimental epilepsy models and resected human brain tissue support the proposed involvement of innate immune system activation and consequent inflammation in epilepsy. Key mediators of this process include interleukin-1β, high-mobility group box protein 1 (HMGB1), and Toll-like receptor (TLR) signaling. These recent findings constitute the basis for a novel avenue of drug development in epilepsy, one that is not only distinct from previous approaches but uniquely based on sound neurobiological evidence.

Entities:  

Year:  2012        PMID： 22368518      PMCID： PMC3280476          DOI： 10.5698/1535-7511-12.1.8

Source DB:  PubMed          Journal:  Epilepsy Curr        ISSN： 1535-7511            Impact factor:   7.500


  51 in total

1.  The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

Authors:  Hulda Sigridur Hreggvidsdottir; Therese Ostberg; Heidi Wähämaa; Hanna Schierbeck; Ann-Charlotte Aveberger; Lena Klevenvall; Karin Palmblad; Lars Ottosson; Ulf Andersson; Helena Erlandsson Harris
Journal:  J Leukoc Biol       Date:  2009-06-29       Impact factor: 4.962

2.  Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.

Authors:  Mattia Maroso; Silvia Balosso; Teresa Ravizza; Jaron Liu; Eleonora Aronica; Anand M Iyer; Carlo Rossetti; Monica Molteni; Maura Casalgrandi; Angelo A Manfredi; Marco E Bianchi; Annamaria Vezzani
Journal:  Nat Med       Date:  2010-03-28       Impact factor: 53.440

3.  Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1.

Authors:  M Maroso; S Balosso; T Ravizza; J Liu; M E Bianchi; A Vezzani
Journal:  J Intern Med       Date:  2011-10       Impact factor: 8.989

4.  Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells.

Authors:  Carmen Fiuza; Michael Bustin; Shefali Talwar; Margaret Tropea; Eric Gerstenberger; James H Shelhamer; Anthony F Suffredini
Journal:  Blood       Date:  2002-11-27       Impact factor: 22.113

5.  Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.

Authors:  Luisa P Cacheaux; Sebastian Ivens; Yaron David; Alexander J Lakhter; Guy Bar-Klein; Michael Shapira; Uwe Heinemann; Alon Friedman; Daniela Kaufer
Journal:  J Neurosci       Date:  2009-07-15       Impact factor: 6.167

Review 6.  Signaling to NF-kappaB by Toll-like receptors.

Authors:  Taro Kawai; Shizuo Akira
Journal:  Trends Mol Med       Date:  2007-10-29       Impact factor: 11.951

Review 7.  Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy.

Authors:  Alon Friedman; Daniela Kaufer; Uwe Heinemann
Journal:  Epilepsy Res       Date:  2009-04-11       Impact factor: 3.045

8.  Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice.

Authors:  A Vezzani; D Moneta; M Conti; C Richichi; T Ravizza; A De Luigi; M G De Simoni; G Sperk; S Andell-Jonsson; J Lundkvist; K Iverfeldt; T Bartfai
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

9.  CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.

Authors:  P Bezzi; M Domercq; L Brambilla; R Galli; D Schols; E De Clercq; A Vescovi; G Bagetta; G Kollias; J Meldolesi; A Volterra
Journal:  Nat Neurosci       Date:  2001-07       Impact factor: 24.884

10.  Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis.

Authors:  Jiyun V Kim; Silvia S Kang; Michael L Dustin; Dorian B McGavern
Journal:  Nature       Date:  2008-11-16       Impact factor: 49.962
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  19 in total

1.  Mechanisms of Seizure-Induced Inflammation of the Brain: Many Possible Roles for Neuronal COX-2.

Authors:  F Edward Dudek
Journal:  Epilepsy Curr       Date:  2012-05       Impact factor: 7.500

2.  Patterns of association of chronic medical conditions and major depression.

Authors:  S B Patten; J V A Williams; D H Lavorato; J L Wang; N Jetté; T T Sajobi; K M Fiest; A G M Bulloch
Journal:  Epidemiol Psychiatr Sci       Date:  2016-10-27       Impact factor: 6.892

Review 3.  Cannabinoids and Epilepsy.

Authors:  Evan C Rosenberg; Richard W Tsien; Benjamin J Whalley; Orrin Devinsky
Journal:  Neurotherapeutics       Date:  2015-10       Impact factor: 7.620

Review 4.  Epilepsy and innate immune system: A possible immunogenic predisposition and related therapeutic implications.

Authors:  Nassim Matin; Omidreza Tabatabaie; Raffaele Falsaperla; Riccardo Lubrano; Piero Pavone; Fahad Mahmood; Melissa Gullotta; Agostino Serra; Paola Di Mauro; Salvatore Cocuzza; Giovanna Vitaliti
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

5.  Identification of significant immune-related genes for epilepsy via bioinformatics analysis.

Authors:  Xiaodan Luo; Tao Xiang; Hongmi Huang; Lin Ye; Yifei Huang; Yuan Wu
Journal:  Ann Transl Med       Date:  2021-07

6.  Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFβ1 or M-CSF.

Authors:  Amy M Smith; E Scott Graham; Sheryl Xia Feng; Robyn L Oldfield; Peter M Bergin; Edward W Mee; Richard L M Faull; Maurice A Curtis; Mike Dragunow
Journal:  PLoS One       Date:  2013-12-05       Impact factor: 3.240

7.  HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products.

Authors:  Yan Chen; Xian-Jing Huang; Nian Yu; Yuan Xie; Kang Zhang; Fang Wen; Hao Liu; Qing Di
Journal:  PLoS One       Date:  2015-10-20       Impact factor: 3.240

8.  Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.

Authors:  Barbara Bennani-Baiti; Stefan Toegel; Helmut Viernstein; Ernst Urban; Christian R Noe; Idriss M Bennani-Baiti
Journal:  PLoS One       Date:  2015-09-25       Impact factor: 3.240

9.  Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties.

Authors:  Pui-Mun Chan; Gowri Kanagasabapathy; Yee-Shin Tan; Vikineswary Sabaratnam; Umah Rani Kuppusamy
Journal:  Evid Based Complement Alternat Med       Date:  2013-11-25       Impact factor: 2.629

10.  DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity.

Authors:  Marine Yeghiazaryan; Izabela Rutkowska-Wlodarczyk; Anna Konopka; Grzegorz M Wilczyński; Armenuhi Melikyan; Eduard Korkotian; Leszek Kaczmarek; Izabela Figiel
Journal:  PLoS One       Date:  2014-06-11       Impact factor: 3.240
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