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Literature DB >> 22367856

Autophagy favors Brucella melitensis survival in infected macrophages.

Fei Guo¹, Hui Zhang, Chuangfu Chen, Shengwei Hu, Yuanzhi Wang, Jun Qiao, Yan Ren, Ke Zhang, Yong Wang, Guoqing Du.

Abstract

This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.

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Year: 2012 PMID： 22367856 PMCID： PMC6275789 DOI： 10.2478/s11658-012-0009-4

Source DB: PubMed Journal: Cell Mol Biol Lett ISSN： 1425-8153 Impact factor: 5.787

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