OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) is a type of REM parasomnia characterized by complex motor activity during REM sleep. In this study, cyclic alternating pattern (CAP) in patients with idiopathic RBD was analyzed to evaluate the expression of arousal instability of NREM sleep. METHODS: A total of 31 idiopathic RBD patients and age- and gender-matched 21 control subjects were consecutively recruited. Conventional sleep polysomnographic recording parameters and CAP parameters were compared between RBD and the control group. RESULTS: The number of CAP cycles (120.13 ± 113.56, p = 0.007), CAP sequences (20.9 ± 18.15, p < 0.001), CAP index (25.14 ± 24.44, p = 0.017), and CAP rate (24.07 ± 13.22, p = 0.016) were all significantly higher in RBD patients compared to the control group. The increase in CAP sequences was observed in phase A2 and A3 subtypes while phase A1 subtype was significantly lower in RBD patients. A significant positive correlation was observed between disease duration with total CAP time (r = 0.289, p = 0.042) and A3 index (r = 0.32, p = 0.024). There was a negative correlation between the age and A1 index (r = -0.4491, p = 0.0001). CONCLUSION: To our knowledge this is the first polysomnographic clinical study which evaluated CAP parameters in RBD. Increased CAP rate found may be considered as a sign showing that NREM sleep may also be affected in RBD patients. Therefore, CAP analysis may be important to enlighten the pathogenesis of parasomnias.
OBJECTIVE:Rapid eye movement (REM) sleep behavior disorder (RBD) is a type of REM parasomnia characterized by complex motor activity during REM sleep. In this study, cyclic alternating pattern (CAP) in patients with idiopathic RBD was analyzed to evaluate the expression of arousal instability of NREM sleep. METHODS: A total of 31 idiopathic RBD patients and age- and gender-matched 21 control subjects were consecutively recruited. Conventional sleep polysomnographic recording parameters and CAP parameters were compared between RBD and the control group. RESULTS: The number of CAP cycles (120.13 ± 113.56, p = 0.007), CAP sequences (20.9 ± 18.15, p < 0.001), CAP index (25.14 ± 24.44, p = 0.017), and CAP rate (24.07 ± 13.22, p = 0.016) were all significantly higher in RBD patients compared to the control group. The increase in CAP sequences was observed in phase A2 and A3 subtypes while phase A1 subtype was significantly lower in RBD patients. A significant positive correlation was observed between disease duration with total CAP time (r = 0.289, p = 0.042) and A3 index (r = 0.32, p = 0.024). There was a negative correlation between the age and A1 index (r = -0.4491, p = 0.0001). CONCLUSION: To our knowledge this is the first polysomnographic clinical study which evaluated CAP parameters in RBD. Increased CAP rate found may be considered as a sign showing that NREM sleep may also be affected in RBD patients. Therefore, CAP analysis may be important to enlighten the pathogenesis of parasomnias.
Authors: Mario Giovanni Terzano; Liborio Parrino; Arianna Smerieri; Ronald Chervin; Sudhansu Chokroverty; Christian Guilleminault; Max Hirshkowitz; Mark Mahowald; Harvey Moldofsky; Agostino Rosa; Robert Thomas; Arthur Walters Journal: Sleep Med Date: 2002-03 Impact factor: 3.492
Authors: Marco Zucconi; Raffaele Ferri; Richard Allen; Paul Christian Baier; Oliviero Bruni; Sudhansu Chokroverty; Luigi Ferini-Strambi; Stephany Fulda; Diego Garcia-Borreguero; Wayne A Hening; Max Hirshkowitz; Birgit Högl; Magdolna Hornyak; Martin King; Pasquale Montagna; Liborio Parrino; Giuseppe Plazzi; Mario G Terzano Journal: Sleep Med Date: 2006-02-03 Impact factor: 3.492
Authors: Jacques Montplaisir; Jean-Francois Gagnon; Maria Livia Fantini; Ronald B Postuma; Yves Dauvilliers; Alex Desautels; Sylvie Rompré; Jean Paquet Journal: Mov Disord Date: 2010-10-15 Impact factor: 10.338
Authors: Ilonka Eisensehr; Reiner Linke; Klaus Tatsch; Bita Kharraz; Josef F Gildehaus; Christian T Wetter; Claudia Trenkwalder; Johannes Schwarz; Soheyl Noachtar Journal: Sleep Date: 2003-08-01 Impact factor: 5.849