Literature DB >> 22367109

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors.

Edwin G Pérez1, Carolina Méndez-Gálvez, Bruce K Cassels.   

Abstract

Covering: up to the end of 2011. This review covers classical and modern structural modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and analogues, and the pharmacology of these compounds, with emphasis on their interactions with nicotinic receptors. 89 references are cited.

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Year:  2012        PMID： 22367109     DOI： 10.1039/c2np00100d

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  7 in total

1.  The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.

Authors:  Christoph Eibl; Isabelle Tomassoli; Lenka Munoz; Clare Stokes; Roger L Papke; Daniela Gündisch
Journal:  Bioorg Med Chem       Date:  2013-10-05       Impact factor: 3.641

2.  The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.

Authors:  Christoph Eibl; Lenka Munoz; Isabelle Tomassoli; Clare Stokes; Roger L Papke; Daniela Gündisch
Journal:  Bioorg Med Chem       Date:  2013-10-05       Impact factor: 3.641

3.  Probing chemical space with alkaloid-inspired libraries.

Authors:  Michael C McLeod; Gurpreet Singh; James N Plampin; Digamber Rane; Jenna L Wang; Victor W Day; Jeffrey Aubé
Journal:  Nat Chem       Date:  2014-01-19       Impact factor: 24.427

Review 4.  Does Smoking Affect OSA? What about Smoking Cessation?

Authors:  Athanasia Pataka; Seraphim Kotoulas; George Kalamaras; Asterios Tzinas; Ioanna Grigoriou; Nectaria Kasnaki; Paraskevi Argyropoulou
Journal:  J Clin Med       Date:  2022-08-31       Impact factor: 4.964

5.  The Bispidinone Derivative 3,7-Bis-[2-(S)-amino-3-(1H-indol-3-yl)-propionyl]-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one Dihydrochloride Induces an Apoptosis-Mediated Cytotoxic Effect on Pancreatic Cancer Cells In Vitro.

Authors:  Melanie J Predebon; Danielle R Bond; Joshua Brzozowski; Helen Jankowski; Fiona Deane; Mark Tarleton; Aron A Shaw; Adam McCluskey; Michael C Bowyer; Judith Weidenhofer; Christopher J Scarlett
Journal:  Molecules       Date:  2019-01-31       Impact factor: 4.411

6.  Determination of Cytisine and N-Methylcytisine from Selected Plant Extracts by High-Performance Liquid Chromatography and Comparison of Their Cytotoxic Activity.

Authors:  Anna Petruczynik; Karol Wróblewski; Justyna Misiurek; Tomasz Plech; Karolina Szalast; Krzysztof Wojtanowski; Tomasz Mroczek; Grażyna Szymczak; Monika Waksmundzka-Hajnos; Piotr Tutka
Journal:  Toxins (Basel)       Date:  2020-08-29       Impact factor: 4.546

Review 7.  Pyridine alkaloids with activity in the central nervous system.

Authors:  Simon X Lin; Maurice A Curtis; Jonathan Sperry
Journal:  Bioorg Med Chem       Date:  2020-10-16       Impact factor: 3.641
  7 in total

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