| Literature DB >> 22366656 |
Tuan-Ahn N Pham1, Haiyan Che, Phuong-Thuy T Phan, Jae-Won Lee, Sung-Soo Kim, Haeil Park.
Abstract
A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC(50)=4.73 μM) than that of wogonin (IC(50)=7.80 μM).Entities:
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Year: 2012 PMID： 22366656 DOI： 10.1016/j.bmcl.2012.01.135
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823