| Literature DB >> 22366653 |
X Christopher Sheng1, Todd Appleby, Thomas Butler, Ruby Cai, Xiaowu Chen, Aesop Cho, Michael O Clarke, Jeromy Cottell, William E Delaney, Edward Doerffler, John Link, Mingzhe Ji, Rowchanak Pakdaman, Hyung-Jung Pyun, Qiaoyin Wu, Jie Xu, Choung U Kim.
Abstract
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.Entities:
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Year: 2012 PMID： 22366653 DOI： 10.1016/j.bmcl.2012.01.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823