Literature DB >> 22366548

Epigenetics: a key regulator of platyhelminth developmental biology?

Kathrin K Geyer1, Karl F Hoffmann.   

Abstract

The Platyhelminthes (flukes/flatworms) are a large group of derived metazoans beautifully adapted for existence in diversely challenging ecosystems. As tractable examples of development and self-regeneration or as causative agents of aquacultural, veterinary and biomedically-relevant parasitic diseases, the platyhelminths are subject to intensive inter-disciplinary research. Given the complex lifestyles exhibited by individuals within this phylum, we postulate that epigenetic processes feature in many aspects of platyhelminth lifecycle diversity, development and environmentally-driven adaptations. Copyright Â
© 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

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Year:  2012        PMID: 22366548     DOI: 10.1016/j.ijpara.2012.02.003

Source DB:  PubMed          Journal:  Int J Parasitol        ISSN: 0020-7519            Impact factor:   3.981


  10 in total

1.  Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes.

Authors:  Kathrin K Geyer; Iain W Chalmers; Neil Mackintosh; Julie E Hirst; Rory Geoghegan; Mathieu Badets; Peter M Brophy; Klaus Brehm; Karl F Hoffmann
Journal:  BMC Genomics       Date:  2013-07-09       Impact factor: 3.969

Review 2.  Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism.

Authors:  Fei Gao; Rui Wang; Mingyuan Liu
Journal:  Front Physiol       Date:  2014-01-10       Impact factor: 4.566

3.  Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.

Authors:  Timothy P Yoshino; Martha Brown; Xiao-Jun Wu; Colin J Jackson; Ramon Ocadiz-Ruiz; Iain W Chalmers; Marlen Kolb; Cornelis H Hokke; Karl F Hoffmann
Journal:  Int J Parasitol       Date:  2014-05-21       Impact factor: 3.981

4.  Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

Authors:  Kathrin K Geyer; Sabrina E Munshi; Helen L Whiteland; Narcis Fernandez-Fuentes; Dylan W Phillips; Karl F Hoffmann
Journal:  PLoS Pathog       Date:  2018-06-28       Impact factor: 6.823

5.  Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes.

Authors:  Hugo R Vaca; Ana M Celentano; Natalia Macchiaroli; Laura Kamenetzky; Federico Camicia; Mara C Rosenzvit
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2019-02-23       Impact factor: 4.077

6.  The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.

Authors:  Kezia C L Whatley; Gilda Padalino; Helen Whiteland; Kathrin K Geyer; Benjamin J Hulme; Iain W Chalmers; Josephine Forde-Thomas; Salvatore Ferla; Andrea Brancale; Karl F Hoffmann
Journal:  PLoS Negl Trop Dis       Date:  2019-11-15

7.  Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni.

Authors:  Murilo S Amaral; Lucas F Maciel; Gilbert O Silveira; Giovanna G O Olberg; João V P Leite; Lucas K Imamura; Adriana S A Pereira; Patricia A Miyasato; Eliana Nakano; Sergio Verjovski-Almeida
Journal:  Sci Rep       Date:  2020-12-09       Impact factor: 4.379

8.  The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.

Authors:  Hugo Rolando Vaca; Ana María Celentano; María Agustina Toscanini; Tino Heimburg; Ehab Ghazy; Patrik Zeyen; Alexander-Thomas Hauser; Guilherme Oliveira; María Celina Elissondo; Manfred Jung; Wolfgang Sippl; Federico Camicia; Mara Cecilia Rosenzvit
Journal:  PLoS Negl Trop Dis       Date:  2021-03-03

9.  Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni.

Authors:  Gilda Padalino; Salvatore Ferla; Andrea Brancale; Iain W Chalmers; Karl F Hoffmann
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-11-13       Impact factor: 4.077

10.  The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities.

Authors:  Kathrin K Geyer; Sabrina E Munshi; Martin Vickers; Michael Squance; Toby J Wilkinson; Daniel Berrar; Cristian Chaparro; Martin T Swain; Karl F Hoffmann
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-04-01       Impact factor: 4.077

  10 in total

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