BACKGROUND: In breast cancer, little is known about the consequences of co-expression of ERα with the second estrogen receptor, ERβ, and its isoforms in light of their joint prognostic value. Previously reported correlations have been based mostly on independent ERα and ERβ expression levels in breast tumors. PURPOSE: To address whether the expression ratio of ERα and ERβ and its isoforms may be a more important parameter than their absolute levels, we analyzed relative mRNA expression ratios of ERβ1 to ERβ2 and ERα in 74 clinical samples of invasive breast cancer including 39 early-onset and 35 late-onset breast cancers. Expression levels were correlated with clinical and histopathological parameters and disease-free interval. RESULTS: A specific correlation of ERβ1 expression levels with tumor size was detected in early-onset breast cancer patients and of ERβ2 levels with tumor size in late-onset patients. Expression of both ERβ isoforms inversely correlated with expression of the two estrogen regulated genes, progesterone receptor and pS2 in both groups. Higher levels of ERβ2 than ERβ1 isoform were associated with a better outcome in late-onset patients. CONCLUSIONS: Our results suggest that different isoforms of ERβ may be involved in suppression of tumor growth in young and elder patients and may have different prognostic values.
BACKGROUND: In breast cancer, little is known about the consequences of co-expression of ERα with the second estrogen receptor, ERβ, and its isoforms in light of their joint prognostic value. Previously reported correlations have been based mostly on independent ERα and ERβ expression levels in breast tumors. PURPOSE: To address whether the expression ratio of ERα and ERβ and its isoforms may be a more important parameter than their absolute levels, we analyzed relative mRNA expression ratios of ERβ1 to ERβ2 and ERα in 74 clinical samples of invasive breast cancer including 39 early-onset and 35 late-onset breast cancers. Expression levels were correlated with clinical and histopathological parameters and disease-free interval. RESULTS: A specific correlation of ERβ1 expression levels with tumor size was detected in early-onset breast cancerpatients and of ERβ2 levels with tumor size in late-onset patients. Expression of both ERβ isoforms inversely correlated with expression of the two estrogen regulated genes, progesterone receptor and pS2 in both groups. Higher levels of ERβ2 than ERβ1 isoform were associated with a better outcome in late-onset patients. CONCLUSIONS: Our results suggest that different isoforms of ERβ may be involved in suppression of tumor growth in young and elder patients and may have different prognostic values.
Authors: Jinyou Liu; Gangadhara R Sareddy; Mei Zhou; Suryavathi Viswanadhapalli; Xiaonan Li; Zhao Lai; Rajeshwar R Tekmal; Andrew Brenner; Ratna K Vadlamudi Journal: Cancer Res Date: 2018-04-16 Impact factor: 12.701
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Authors: Bashar Zeidan; Antigoni Manousopoulou; Diana J Garay-Baquero; Cory H White; Samantha E T Larkin; Kathleen N Potter; Theodoros I Roumeliotis; Evangelia K Papachristou; Ellen Copson; Ramsey I Cutress; Stephen A Beers; Diana Eccles; Paul A Townsend; Spiros D Garbis Journal: Breast Cancer Res Date: 2018-03-22 Impact factor: 6.466
Authors: Yi He; Salvador Alejo; Prabhakar Pitta Venkata; Jessica D Johnson; Ilanna Loeffel; Uday P Pratap; Yi Zou; Zhao Lai; Rajeshwar R Tekmal; Edward R Kost; Gangadhara R Sareddy Journal: Int J Mol Sci Date: 2022-06-28 Impact factor: 6.208