| Literature DB >> 22365656 |
Bettina M Kofler1, Elizabeth A Miles, Peter Curtis, Christopher K Armah, Sabine Tricon, Jilly Grew, Frances L Napper, Leslie Farrell, Georg Lietz, Christopher J Packard, Muriel J Caslake, John C Mathers, Christine M Williams, Philip C Calder, Anne Marie Minihane.
Abstract
Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype × BMI/age/sex interactions. APOE genotype had a significant impact on fasting total:LDL-cholesterol (TC:LDL-C) ratio, triglycerides, % HDL3, and the Framingham 10-year CVD risk score (P<0.05), with an overall trend towards lower and higher risk in E2- and E4-carriers, respectively, relative to the wild-type E3/E3 genotype. A greater impact of genotype on TC:HDL-C was observed in females, which explained 16% of the variability in this outcome versus 6% in males. APOE genotype was also associated with plasma C-reactive protein and adhesion molecule concentrations (P<0.05), with significant genotype × BMI interactions observed. Our observations indicate that the association between the APOE genotype and CHD risk is unlikely to be homogenous and highlights the risk of inaccurate estimations of genotype-phenotype associations in population subgroups without appropriate stratification for sex and adiposity.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22365656 DOI： 10.1016/j.atherosclerosis.2012.01.042
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162