Literature DB >> 22365599

Exploiting effectors of Rac GTPase.

Hakryul Jo1, Hongbo R Luo.   

Abstract

Targeting a specific arm of signaling pathways is of great interest. In this issue of Chemistry & Biology, Bosco et al. exploit the interactive interface between Rac GTPase and its effector p67(phox) to specifically inhibit reactive oxygen species production without perturbing other Rac-mediated cellular processes.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22365599      PMCID： PMC3292760          DOI： 10.1016/j.chembiol.2012.02.001

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  7 in total

1.  Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

Authors:  Yuan Gao; J Bradley Dickerson; Fukun Guo; Jie Zheng; Yi Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-05       Impact factor: 11.205

2.  Virtual screening approach for the identification of new Rac1 inhibitors.

Authors:  Nicola Ferri; Alberto Corsini; Paolo Bottino; Francesca Clerici; Alessandro Contini
Journal:  J Med Chem       Date:  2009-07-23       Impact factor: 7.446

3.  Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.

Authors:  Hidenori Hattori; Kulandayan K Subramanian; Jiro Sakai; Yonghui Jia; Yitang Li; Timothy F Porter; Fabien Loison; Bara Sarraj; Anongnard Kasorn; Hakryul Jo; Catlyn Blanchard; Dorothy Zirkle; Douglas McDonald; Sung-Yun Pai; Charles N Serhan; Hongbo R Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-08       Impact factor: 11.205

Review 4.  The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.

Authors:  Karen Bedard; Karl-Heinz Krause
Journal:  Physiol Rev       Date:  2007-01       Impact factor: 37.312

5.  Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.

Authors:  Christoph Kleinschnitz; Henrike Grund; Kirstin Wingler; Melanie E Armitage; Emma Jones; Manish Mittal; David Barit; Tobias Schwarz; Christian Geis; Peter Kraft; Konstanze Barthel; Michael K Schuhmann; Alexander M Herrmann; Sven G Meuth; Guido Stoll; Sabine Meurer; Anja Schrewe; Lore Becker; Valérie Gailus-Durner; Helmut Fuchs; Thomas Klopstock; Martin Hrabé de Angelis; Karin Jandeleit-Dahm; Ajay M Shah; Norbert Weissmann; Harald H H W Schmidt
Journal:  PLoS Biol       Date:  2010-09-21       Impact factor: 8.029

Review 6.  NADPH oxidase inhibitors: new antihypertensive agents?

Authors:  Holly C Williams; Kathy K Griendling
Journal:  J Cardiovasc Pharmacol       Date:  2007-07       Impact factor: 3.105

7.  Structure of the TPR domain of p67phox in complex with Rac.GTP.

Authors:  K Lapouge; S J Smith; P A Walker; S J Gamblin; S J Smerdon; K Rittinger
Journal:  Mol Cell       Date:  2000-10       Impact factor: 17.970
  7 in total
  1 in total

1.  Inhibition of Rac family protein impairs colitis and colitis-associated cancer in mice.

Authors:  Yandong Guo; Jing Xiong; Jing Wang; Jing Wen; Fachao Zhi
Journal:  Am J Cancer Res       Date:  2018-01-01       Impact factor: 6.166
  1 in total

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