OBJECTIVE: Superoxide dismutase, glutathione peroxidase, and catalase prevent cellular damage produced by free radicals. Our objective was to evaluate if prenatal alcohol exposure decreased the expression of antioxidant enzymes in the brain, liver, or placenta of fetal mice. STUDY DESIGN: Timed, pregnant C57BL6/J mice were treated on gestational day 8 with intraperitoneal injection of alcohol (0.03 mL/g) or saline (control). Fetuses were harvested on gestational day 18. Fetal brain, liver, and placenta were analyzed for mRNA expression of superoxide dismutase, glutathione peroxidase, and catalase by real-time polymerase chain reaction, with 18S RNA used as reference. RESULTS: Superoxide dismutase, glutathione peroxidase, and catalase expression was lower in fetal brains exposed to alcohol with no differences detected in the liver or placenta between the 2 groups. CONCLUSION: Maternal alcohol consumption causes a decrease in superoxide dismutase, glutathione peroxidase, and catalase expression in the fetal brain. This may explain the long-term neurologic findings in fetal alcohol syndrome.
OBJECTIVE:Superoxide dismutase, glutathione peroxidase, and catalase prevent cellular damage produced by free radicals. Our objective was to evaluate if prenatal alcohol exposure decreased the expression of antioxidant enzymes in the brain, liver, or placenta of fetal mice. STUDY DESIGN: Timed, pregnant C57BL6/J mice were treated on gestational day 8 with intraperitoneal injection of alcohol (0.03 mL/g) or saline (control). Fetuses were harvested on gestational day 18. Fetal brain, liver, and placenta were analyzed for mRNA expression of superoxide dismutase, glutathione peroxidase, and catalase by real-time polymerase chain reaction, with 18S RNA used as reference. RESULTS:Superoxide dismutase, glutathione peroxidase, and catalase expression was lower in fetal brains exposed to alcohol with no differences detected in the liver or placenta between the 2 groups. CONCLUSION:Maternal alcohol consumption causes a decrease in superoxide dismutase, glutathione peroxidase, and catalase expression in the fetal brain. This may explain the long-term neurologic findings in fetal alcohol syndrome.
Authors: M E Götz; B Janetzky; S Pohli; A Gottschalk; W Gsell; T Tatschner; G Ransmayr; F Leblhuber; M Gerlach; H Reichmann; P Riederer ; J Böning Journal: Alcohol Clin Exp Res Date: 2001-05 Impact factor: 3.455
Authors: Abdullah Kumral; Kazim Tugyan; Sevil Gonenc; Kursat Genc; Sermin Genc; Ulker Sonmez; Osman Yilmaz; Nuray Duman; Nazan Uysal; Hasan Ozkan Journal: Brain Res Dev Brain Res Date: 2005-10-19
Authors: Min Ji Bak; Van-Long Truong; Se-Yeon Ko; Xuan Ngan Giang Nguyen; Pajaree Ingkasupart; Mira Jun; Jin Young Shin; Woo-Sik Jeong Journal: Int J Mol Sci Date: 2016-05-18 Impact factor: 5.923