| Literature DB >> 2236297 |
A Nahrstedt1, M Albrecht, V Wray, H G Gumbinger, M John, H Winterhoff, F H Kemper.
Abstract
Two new cyclolignan derivatives were isolated by HPLC from the mixture of substances obtained after oxidation of caffeic acid with KMnO4. Their structures were elucidated by spectroscopic methods as 2,3-dicarboxy-6,7-dihydroxy-1-(3', 4'-dihydroxy)-phenyl-1, 2-dihydronaphthalene (1) and 3-carboxy-6,7-dihydroxy-1-(3', 4'-dihydroxy)-phenylnaphthalene (2). Compounds 1 and 2 exhibit antigonadotropic activity as do the extracts of crude drugs of Lycopus europaeus and Lithospermum officinale after oxidation by plant enzymes.Entities:
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Year: 1990 PMID： 2236297 DOI： 10.1055/s-2006-960992
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352