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Literature DB >> 2236294

The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.

D J Pan¹, Z L Li, C Q Hu, K Chen, J J Chang, K H Lee.

Abstract

Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.

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Year: 1990 PMID： 2236294 DOI： 10.1055/s-2006-960989

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

11 in total

1. Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells.

Authors: Li Hou; Bo Xu; Wei Guo; Fu-Xiang Ran; Jing-Tao Liu; Xia Yuan; Hong-Zheng Fu; Jing-Rong Cui
Journal: J Cancer Res Clin Oncol Date: 2012-05 Impact factor: 4.553

2. Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis.

Authors: Ke-Shen Li; Xue-Feng Gu; Ping Li; Yong Zhang; Ya-Shuang Zhao; Zhen-Jiang Yao; Nai-Qiang Qu; Bin-You Wang
Journal: World J Gastroenterol Date: 2005-12-28 Impact factor: 5.742

3. Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B.

Authors: Guoyi Ma; Li Chong; Xing-Cong Li; Ikhlas A Khan; Larry A Walker; Shabana I Khan
Journal: J Cancer Res Clin Oncol Date: 2010-02-07 Impact factor: 4.553

The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.

1. Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells.

2. Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis.

3. Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B.

4. Total synthesis of (-)-pseudolaric acid B.

5. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death.

Review 6. Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).

7. A review on plant-derived natural products and their analogs with anti-tumor activity.

8. Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.

9. Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell.

10. Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.