Literature DB >> 22362106

Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines.

Hiroyuki Kawai1, Takashi Kitayama, Etsuko Tokunaga, Takashi Matsumoto, Hiroyasu Sato, Motoo Shiro, Norio Shibata.   

Abstract

Enantioselective synthesis of β-trifluoromethylated pyrrolines has been developed by the organocatalyzed-conjugated addition of nitromethane to β-trifluoromethylated enones, followed by a nitro-reduction/cyclization/dehydration sequence in a one-pot procedure with 97-98% ees. This journal is © The Royal Society of Chemistry 2012

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Year:  2012        PMID： 22362106     DOI： 10.1039/c2cc18049a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Access to benzo-fused nine-membered heterocyclic alkenes with a trifluoromethyl carbinol moiety via a double decarboxylative formal ring-expansion process under palladium catalysis.

Authors:  Pulakesh Das; Satoshi Gondo; Punna Nagender; Hiroto Uno; Etsuko Tokunaga; Norio Shibata
Journal:  Chem Sci       Date:  2018-02-23       Impact factor: 9.825

Review 2.  Metal-mediated synthesis of pyrrolines.

Authors:  Noelia S Medran; Agustina La-Venia; Sebastian A Testero
Journal:  RSC Adv       Date:  2019-02-27       Impact factor: 4.036
  2 in total

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