INTRODUCTION: Minocycline is an antibiotic used for the treatment of acne. It has been associated with several autoimmune syndromes, including drug-induced lupus, autoimmune hepatitis, and vasculitis. METHOD AND RESULTS: We report a case of a 28-year-old previously healthy woman who developed a left sciatic mononeuropathy 2 weeks after starting minocycline for acne. Magnetic resonance imaging studies supported the localization. A biopsy of the left sural nerve revealed acute nerve large arteriole necrotizing vasculitis. Her condition improved after the withdrawal of minocycline and a course of treatment with methylprednisolone. CONCLUSION: This case provides further evidence that minocycline may induce a nonsystemic necrotizing vasculitis.
INTRODUCTION:Minocycline is an antibiotic used for the treatment of acne. It has been associated with several autoimmune syndromes, including drug-induced lupus, autoimmune hepatitis, and vasculitis. METHOD AND RESULTS: We report a case of a 28-year-old previously healthy woman who developed a left sciatic mononeuropathy 2 weeks after starting minocycline for acne. Magnetic resonance imaging studies supported the localization. A biopsy of the left sural nerve revealed acute nerve large arteriole necrotizing vasculitis. Her condition improved after the withdrawal of minocycline and a course of treatment with methylprednisolone. CONCLUSION: This case provides further evidence that minocycline may induce a nonsystemic necrotizing vasculitis.
Authors: Neha Garg; Gadah H Altowaijri; Gary M Nesbit; Sakir Humayun Gultekin; Dennis N Bourdette Journal: Neurol Neuroimmunol Neuroinflamm Date: 2014-05-15
Authors: John M Baratta; P James B Dyck; Patricio Brand; Pariwat Thaisetthawatkul; Peter J Dyck; JaNean K Engelstad; Brent Goodman; Chafic Karam Journal: Neurol Neuroimmunol Neuroinflamm Date: 2015-11-12