Literature DB >> 22360360

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas.

Joanna Bielanska1, Javier Hernández-Losa, Teresa Moline, Rosa Somoza, Santiago Ramón y Cajal, Enric Condom, Joan Carles Ferreres, Antonio Felipe.   

Abstract

Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy.

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Year:  2012        PMID： 22360360     DOI： 10.3109/07357907.2012.654872

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  11 in total

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4.  Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness.

Authors:  Joanna Bielanska; Javier Hernández-Losa; Teresa Moline; Rosa Somoza; Santiago Ramón Y Cajal; Enric Condom; Joan Carles Ferreres; Antonio Felipe
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Authors:  Charles A Galea; Hai M Nguyen; K George Chandy; Brian J Smith; Raymond S Norton
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6.  Expression of KCNA5 Protein in Human Mammary Epithelial Cell Line Associated with Caveolin-1.

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7.  The Potassium Channel Kv1.5 Expression Alters During Experimental Autoimmune Encephalomyelitis.

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8.  Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.

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Review 10.  The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.

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Journal:  Front Physiol       Date:  2013-10-10       Impact factor: 4.566
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