| Literature DB >> 22359294 |
Josena K Stephen1, Kang Mei Chen, Shaleta Havard, Glynis Harris, Maria J Worsham.
Abstract
In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.Entities:
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Year: 2012 PMID: 22359294 PMCID: PMC3723335 DOI: 10.1007/978-1-61779-612-8_11
Source DB: PubMed Journal: Methods Mol Biol ISSN: 1064-3745