Literature DB >> 22358964

On the mode of action ofClostridium difficile toxin A: anin vitro study.

C Fiorentini1, G Donelli, P Nicotera, P Mastrantonio, M Thelestam.   

Abstract

C. difficile toxin A causes the rounding up and the formation of surface blebs in normal rat intestinal crypt cells (IEC-6). These phenomena, together with the inhibition of DNA synthesis and the cell lysis, could be the mechanisms leading the toxin-treated cells to death.

Entities:  

Year:  1991        PMID： 22358964     DOI： 10.1007/BF00736818

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  3 in total

1.  Effects of Clostridium difficile toxins A and B on cytoskeleton organization in HEp-2 cells: a comparative morphological study.

Authors:  C Fiorentini; G Arancia; S Paradisi; G Donelli; M Giuliano; F Piemonte; P Mastrantonio
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

2.  Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization.

Authors:  C Fiorentini; W Malorni; S Paradisi; M Giuliano; P Mastrantonio; G Donelli
Journal:  Infect Immun       Date:  1990-07       Impact factor: 3.441

3.  Surface blebbing and cytoskeletal changes induced in vitro by toxin B from Clostridium difficile: an immunochemical and ultrastructural study.

Authors:  W Malorni; C Fiorentini; S Paradisi; M Giuliano; P Mastrantonio; G Donelli
Journal:  Exp Mol Pathol       Date:  1990-06       Impact factor: 3.362
  3 in total

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