Literature DB >> 22358899

In vitro promoting activity of human interferon β production by extracts of marine algae from Japan.

T Nakano, T Noro, Y Kamei.   

Abstract

Two hundreds species of marine algae were investigated for in vitro promoting activity of human interferon β (IFN-β) production by poly(I:C)-induced human osteosarcoma cell line, MG-63. A brown alga, Sargassum hemipyllum promoted most its activity, showing more than 11-fold. When we attempted to partially purify the active substances by particular two-step chromatography, two peaks of active fractions were obtained. These fractioned materials exhibited the heat-stable and non-cytotoxic characters with the molecular weight less than 3000.

Entities:  

Year:  1997        PMID： 22358899      PMCID： PMC3466757          DOI： 10.1023/A:1007939127679

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  8 in total

Review 1.  The interferon system. A bird's eye view of its biochemistry.

Authors:  G C Sen; P Lengyel
Journal:  J Biol Chem       Date:  1992-03-15       Impact factor: 5.157

Review 2.  The interferons. Mechanisms of action and clinical applications.

Authors:  S Baron; S K Tyring; W R Fleischmann; D H Coppenhaver; D W Niesel; G R Klimpel; G J Stanton; T K Hughes
Journal:  JAMA       Date:  1991-09-11       Impact factor: 56.272

3.  Selective antitumor activity in vitro from marine algae from Japan coasts.

Authors:  H Harada; T Noro; Y Kamei
Journal:  Biol Pharm Bull       Date:  1997-05       Impact factor: 2.233

4.  Activation of interferon-inducible genes in vivo by synthetic double-stranded RNA, poly rI:rC.

Authors:  M Gariglio; S Panico; G Gribaudo; M G Martinotti; G Cavallo; S Landolfo
Journal:  Microbiologica       Date:  1991-07

5.  Prophylactic and therapeutic efficacies of poly(IC.LC) against respiratory influenza A virus infection in mice.

Authors:  J P Wong; E G Saravolac; D Sabuda; H B Levy; M Kende
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

6.  Regulation of cellular interferon production: enhancement by antimetabolites.

Authors:  Y H Tan; J A Armstrong; Y H Ke; M Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

7.  Enhancement of production of IgM and interferon-beta in human cell lines by poly-lysine.

Authors:  M M Yamamoto; Y Mori; K Osada; H Murakami
Journal:  Biosci Biotechnol Biochem       Date:  1995-10       Impact factor: 2.043
  8 in total

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