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Literature DB >> 2235887

Diffusion in porous materials above the percolation threshold.

Abstract

The diffusion of water-soluble solutes in water-soaked porous media was studied by following the release of benzoic acid from poly(vinyl stearate) matrices. The results were analyzed using a pseudo-steady-state diffusion model coupled with the fundamental concepts of percolation theory. The results of the study indicated that the relationship between the bulk diffusion coefficient of benzoic acid in the polymer matrix and the porosity was well described by percolation scaling laws. A very low percolation threshold (0.07) was experimentally observed for this system.

Entities: Chemical

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Year: 1990 PMID： 2235887 DOI： 10.1023/a:1015985521029

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

8 in total

1. MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.

Authors: T HIGUCHI
Journal: J Pharm Sci Date: 1963-12 Impact factor: 3.534

2. Rate of release of medicaments from ointment bases containing drugs in suspension.

Authors: T HIGUCHI
Journal: J Pharm Sci Date: 1961-10 Impact factor: 3.534

3. Electrical-conductivity fluctuations near the percolation threshold.

Authors:
Journal: Phys Rev Lett Date: 1985-06-10 Impact factor: 9.161

4. Controlled release of polypeptides and other macromolecules.

Authors: R A Siegel; R Langer
Journal: Pharm Res Date: 1984-01 Impact factor: 4.200

5. Measurement of the conductivity exponent in two-dimensional percolating networks: square lattice versus random-void continuum.

Authors:
Journal: Phys Rev B Condens Matter Date: 1985-12-01

6. Drug release from wax matrices. II. Application of a mixture theory to the suflanilamide--wax system.

Authors: J B Schwartz; A P Simonelli; W I Higuchi
Journal: J Pharm Sci Date: 1968-02 Impact factor: 3.534

7. The role of polymer matrix structure and interparticle interactions in diffusion-limited drug release.

Authors: A C Balazs; D F Calef; J M Deutch; R A Siegel; R Langer
Journal: Biophys J Date: 1985-01 Impact factor: 4.033

8. Polymers for the controlled release of macromolecules: effect of molecular weight of ethylene-vinyl acetate copolymer.

Authors: T T Hsu; R Langer
Journal: J Biomed Mater Res Date: 1985-04

8 in total

5 in total

Diffusion in porous materials above the percolation threshold.

1. MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.

2. Rate of release of medicaments from ointment bases containing drugs in suspension.

3. Electrical-conductivity fluctuations near the percolation threshold.

4. Controlled release of polypeptides and other macromolecules.

5. Measurement of the conductivity exponent in two-dimensional percolating networks: square lattice versus random-void continuum.

6. Drug release from wax matrices. II. Application of a mixture theory to the suflanilamide--wax system.

7. The role of polymer matrix structure and interparticle interactions in diffusion-limited drug release.

8. Polymers for the controlled release of macromolecules: effect of molecular weight of ethylene-vinyl acetate copolymer.

1. An assessment of reasonable tortuosity values.

2. Relationship between drug percolation threshold and particle size in matrix tablets.

3. Modeling of aqueous transport in rigid porous matrices near the percolation threshold.

4. Percolative transport and cluster diffusion near and below the percolation threshold of a porous polymeric matrix.

5. Polymer Percolation Threshold in Multi-Component HPMC Matrices Tablets.