Literature DB >> 22358710

Interaction ofEscherichia coli cytotoxic necrotizing factor type 1 (CNF1) with cultured cells.

L Falzano1, C Fiorentini, P Boquet, G Donelli.   

Abstract

The cytotoxic necrotizing factor type 1 (CNF1) fromE. coli causes necrosis in rabbit skin and multinucleation in cultured cells. Cells exposed to CNF1 were characterized by changes in actin organization, mainly consisting in the presence of well-developed stress fibers and membrane ruffles. The interaction of CNF1 with the cell cytoskeleton probably promotes the cell spreading and interferes with the cytokinesis, leading to the formation of giant multinucleated cells.

Entities:  

Year:  1993        PMID： 22358710     DOI： 10.1007/BF00746055

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  4 in total

1.  Cytoskeletal changes induced in HEp-2 cells by the cytotoxic necrotizing factor of Escherichia coli.

Authors:  C Fiorentini; G Arancia; A Caprioli; V Falbo; F M Ruggeri; G Donelli
Journal:  Toxicon       Date:  1988       Impact factor: 3.033

2.  Gene block encoding production of cytotoxic necrotizing factor 1 and hemolysin in Escherichia coli isolates from extraintestinal infections.

Authors:  V Falbo; M Famiglietti; A Caprioli
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

3.  Cytotoxic necrotizing factor production by hemolytic strains of Escherichia coli causing extraintestinal infections.

Authors:  A Caprioli; V Falbo; F M Ruggeri; L Baldassarri; R Bisicchia; G Ippolito; E Romoli; G Donelli
Journal:  J Clin Microbiol       Date:  1987-01       Impact factor: 5.948

4.  Partial purification and characterization of an escherichia coli toxic factor that induces morphological cell alterations.

Authors:  A Caprioli; V Falbo; L G Roda; F M Ruggeri; C Zona
Journal:  Infect Immun       Date:  1983-03       Impact factor: 3.441
  4 in total
  2 in total

1.  The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study.

Authors:  Alessia Fabbri; Sara Travaglione; Zaira Maroccia; Marco Guidotti; Ciro Leonardo Pierri; Guido Primiano; Serenella Servidei; Stefano Loizzo; Carla Fiorentini
Journal:  Int J Mol Sci       Date:  2018-06-21       Impact factor: 5.923

2.  CTX-CNF1 Recombinant Protein Selectively Targets Glioma Cells In Vivo.

Authors:  Eleonora Vannini; Elisabetta Mori; Elena Tantillo; Gudula Schmidt; Matteo Caleo; Mario Costa
Journal:  Toxins (Basel)       Date:  2021-03-08       Impact factor: 4.546
  2 in total

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