Literature DB >> 22358672

Cerebellar neurones: Differentiation and modulation of sensitivity to excitotoxic treatment.

D Mercanti1, A Angelini, M Ciotti, M Eboli, C Galli, L Battistini, D Merlo, P Calissano.   

Abstract

The neurite outgrowth and adhesion complex (NOAC), isolated from rabbit sera has been dissociated in its major components by reverse-phase chromatography in HPLC by using a C(18) column. SDS-PAGE analisys of the active fractions revealed the presence of three major bands of approximately 100, 70 and 50 kDa. Studies on the biological activity of NOAC were carried out on rat cerebellar granule cells. NOAC-cultured cells exhibit a marked resistance to excitotoxic stimuli carried by glutamate.

Entities:  

Year:  1993        PMID： 22358672     DOI： 10.1007/BF00746073

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  2 in total

1.  Identification of the Serum Complex Which Induces Cerebellar Granule Cell In Vitro Differentiation and Resistance to Excitatory Amino Acids.

Authors:  D. Mercanti; C. Galli; M. Liguori; M. T. Ciotti; P. Gullà; P. Calissano
Journal:  Eur J Neurosci       Date:  1992       Impact factor: 3.386

2.  Differential involvement of protein kinase C in transmitter release and response to excitatory amino acids in cultured cerebellar neurons.

Authors:  M L Eboli; M T Ciotti; D Mercanti; P Calissano
Journal:  Neurochem Res       Date:  1993-02       Impact factor: 3.996
  2 in total

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