Literature DB >> 22358564

CG Dinucleotides of class II MHC genes are mutation hot-spots.

R Gambari1, R Piva, S Volinia, P Orlando, C Nastruzzi, P Giacomini, P G Natali, R Barbieri.   

Abstract

DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription.

Entities:  

Year:  1988        PMID： 22358564     DOI： 10.1007/BF00146813

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  8 in total

1.  Serologic and immunochemical characterization of the specificity of four monoclonal antibodies to distinct antigenic determinants expressed on subpopulations of human Ia-like antigens.

Authors:  V Quaranta; M A Pellegrino; S Ferrone
Journal:  J Immunol       Date:  1981-02       Impact factor: 5.422

2.  Analysis by molecular cloning of the human class II genes.

Authors:  H Erlich; D Stetler; R Sheng-Dong; R Saiki
Journal:  Fed Proc       Date:  1984-12

3.  Differential inhibition of HLA-D- or SB-directed secondary lymphoproliferative responses with monoclonal antibodies detecting human Ia-like determinants.

Authors:  G P Pawelec; S Shaw; A Ziegler; C Müller; P Wernet
Journal:  J Immunol       Date:  1982-09       Impact factor: 5.422

4.  Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

Authors:  B A White; F C Bancroft
Journal:  J Biol Chem       Date:  1982-08-10       Impact factor: 5.157

5.  Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.

Authors:  C Auffray; J W Lillie; D Arnot; D Grossberger; D Kappes; J L Strominger
Journal:  Nature       Date:  1984 Mar 22-28       Impact factor: 49.962

6.  CG dinucleotide clusters in MHC genes and in 5' demethylated genes.

Authors:  M L Tykocinski; E E Max
Journal:  Nucleic Acids Res       Date:  1984-05-25       Impact factor: 16.971

7.  Human leukemic K562 cells: suppression of hemoglobin accumulation by a monoclonal antibody to human transferrin receptor.

Authors:  R Gambari; R Barbieri; D Buzzoni; F Bernardi; G Marchetti; F Amelotti; R Piva; L Viola; L del Senno
Journal:  Biochim Biophys Acta       Date:  1986-04-29

8.  Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

Authors:  D Larhammar; K Gustafsson; L Claesson; P Bill; K Wiman; L Schenning; J Sundelin; E Widmark; P A Peterson; L Rask
Journal:  Cell       Date:  1982-08       Impact factor: 41.582
  8 in total
  1 in total

1.  Hypomethylation of the human HLA-DR alpha gene in breast carcinomas and autologous metastases.

Authors:  R Barbieri; A P Rimondi; D Buzzoni; L Luppi; C Nastruzzi; P Orlando; R Gambari
Journal:  Clin Exp Metastasis       Date:  1989 Jul-Aug       Impact factor: 5.150
  1 in total

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