BACKGROUND: In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. METHODS:One hundred twenty female patients were randomly assigned to one of three groups to receive antiemetics as follows: ramosetron 0.3 mg (group R), dexamethasone 8 mg (group D), or ramosetron 0.3 mg combined with dexamethasone 8 mg (group RD). PONV, postoperative pain intensity, rescue antiemetics requirement, and side effects were assessed at 0-6, 6-12, and 12-24 h after surgery. RESULTS: The ratio of complete response (no PONV and no rescue antiemetic) was higher at 6-12 h in groups R and RD than in group D (p < 0.05) and at 12-24 h in group RD than in group D (p < 0.05). The incidence of nausea was lower at 6-12 h in groups R (p = 0.043) and RD (p = 0.003) compared to group D and at 12-24 h in group RD (p = 0.01) compared to group D. The severity of nausea was also significantly reduced at 6-12 h in groups R and RD compared to group D (p < 0.05). There were no clinically serious adverse events related to the studied drugs. CONCLUSION:Antiemetic efficacy of the combination of ramosetron 0.3 mg and dexamethasone 8 mg for PONV was most superior, with 93% of the patients showing complete response at 12-24 h after surgery followed by ramosetron alone and dexamethasone alone.
RCT Entities:
BACKGROUND: In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. METHODS: One hundred twenty female patients were randomly assigned to one of three groups to receive antiemetics as follows: ramosetron 0.3 mg (group R), dexamethasone 8 mg (group D), or ramosetron 0.3 mg combined with dexamethasone 8 mg (group RD). PONV, postoperative pain intensity, rescue antiemetics requirement, and side effects were assessed at 0-6, 6-12, and 12-24 h after surgery. RESULTS: The ratio of complete response (no PONV and no rescue antiemetic) was higher at 6-12 h in groups R and RD than in group D (p < 0.05) and at 12-24 h in group RD than in group D (p < 0.05). The incidence of nausea was lower at 6-12 h in groups R (p = 0.043) and RD (p = 0.003) compared to group D and at 12-24 h in group RD (p = 0.01) compared to group D. The severity of nausea was also significantly reduced at 6-12 h in groups R and RD compared to group D (p < 0.05). There were no clinically serious adverse events related to the studied drugs. CONCLUSION: Antiemetic efficacy of the combination of ramosetron 0.3 mg and dexamethasone 8 mg for PONV was most superior, with 93% of the patients showing complete response at 12-24 h after surgery followed by ramosetron alone and dexamethasone alone.
Authors: Tong J Gan; Tricia A Meyer; Christian C Apfel; Frances Chung; Peter J Davis; Ashraf S Habib; Vallire D Hooper; Anthony L Kovac; Peter Kranke; Paul Myles; Beverly K Philip; Gregory Samsa; Daniel I Sessler; James Temo; Martin R Tramèr; Craig Vander Kolk; Mehernoor Watcha Journal: Anesth Analg Date: 2007-12 Impact factor: 5.108
Authors: Glenn S Murphy; Joseph W Szokol; Steven B Greenberg; Michael J Avram; Jeffery S Vender; Margarita Nisman; Jessica Vaughn Journal: Anesthesiology Date: 2011-04 Impact factor: 7.892
Authors: Sevgi Bilgen; Nurcan Kızılcık; Murat Haliloğlu; Gazi Yıldırım; Elif Çiğdem Kaspar; Özge Köner Journal: Turk J Anaesthesiol Reanim Date: 2018-09-04
Authors: Stephanie Weibel; Gerta Rücker; Leopold Hj Eberhart; Nathan L Pace; Hannah M Hartl; Olivia L Jordan; Debora Mayer; Manuel Riemer; Maximilian S Schaefer; Diana Raj; Insa Backhaus; Antonia Helf; Tobias Schlesinger; Peter Kienbaum; Peter Kranke Journal: Cochrane Database Syst Rev Date: 2020-10-19
Authors: HyunJeong Kwak; Young Jin Chang; Kyung Cheon Lee; Wol Seon Jung; Sunkoo Kwon; Youn Yi Jo Journal: J Int Med Res Date: 2019-09-11 Impact factor: 1.671
Authors: Jung Woo Park; Jin Woo Jun; Yun Hee Lim; Sang Seok Lee; Byung Hoon Yoo; Kye-Min Kim; Jun Heum Yon; Ki Hyuk Hong Journal: Korean J Anesthesiol Date: 2012-10-12