| Literature DB >> 22357696 |
Meir Shamay1, Nicholas Hand, M Victor Lemas, Henry B Koon, Susan E Krown, John Wrangle, Prashant Desai, Juan Carlos Ramos, Richard F Ambinder.
Abstract
We studied the presence of Kaposi sarcoma herpesvirus sequences in cell-free DNA (cfDNA) isolated from the blood of patients with AIDS-related Kaposi sarcoma (KS) and primary effusion lymphoma (PEL). The use of paramagnetic beads linked to methyl-CpG binding domain protein allowed separation of virion and cell-derived DNA. Only virion DNA was detected in the blood of KS patients, whereas cell-derived DNA was detected in a patient with AIDS-related PEL. The difference in the origins of cfDNA in these settings may in part reflect very different proliferative indices in KS and PEL tumor tissue.Entities:
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Year: 2012 PMID: 22357696 PMCID: PMC3295606 DOI: 10.1093/infdis/jis032
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226