I Tramacere1, C Pelucchi2, M Bonifazi1, V Bagnardi3, M Rota4, R Bellocco5, L Scotti6, F Islami7, G Corrao6, P Boffetta8, C La Vecchia9, E Negri1. 1. Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan. 2. Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan. Electronic address: claudio.pelucchi@marionegri.it. 3. Department of Statistics, University of Milano-Bicocca, Milan; Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan. 4. Department of Statistics, University of Milano-Bicocca, Milan; Department of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Monza, Italy. 5. Department of Statistics, University of Milano-Bicocca, Milan; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 6. Department of Statistics, University of Milano-Bicocca, Milan. 7. International Agency for Research on Cancer, Lyon, France; Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA. 8. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA; International Prevention Research Institute, Lyon, France. 9. Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan; Department of Occupational Health, University of Milano, Milan, Italy.
Abstract
BACKGROUND: Whether an association between alcohol drinking and non-Hodgkin lymphoma (NHL) risk exists is an open question. In order to provide quantification of the issue, we carried out a meta-analysis of published data. METHODS: We identified 21 case-control and 8 cohort studies, including a total of 18,759 NHL cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. RESULTS: The overall relative risk (RR) of NHL for drinkers versus non-drinkers was 0.85 [95% confidence interval (CI) 0.79-0.91]. Compared with non-drinkers, the pooled RRs were 0.88 for light (≤1 drink per day), 0.87 for moderate (1 to <4 drinks per day), and 0.84 for heavy (≥4 drinks per day) alcohol drinking. There was no association for light drinkers in cohort studies, whereas for moderate and heavy drinkers, the RRs were similar in case-control (0.85 for moderate, 0.92 for heavy) and cohort (0.89 for moderate, 0.79 for heavy) studies. The inverse relation with alcohol consumption (drinkers versus non-drinkers) was similar in men (RR = 0.83) and women (RR = 0.86), but apparently stronger in studies from Asia (RR = 0.69) than other world areas (RR = 0.88). CONCLUSION: This meta-analysis provides quantitative evidence of a favourable role of alcohol drinking on NHL risk, though the lack of a biological explanation suggests caution in the interpretation of results.
BACKGROUND: Whether an association between alcohol drinking and non-Hodgkin lymphoma (NHL) risk exists is an open question. In order to provide quantification of the issue, we carried out a meta-analysis of published data. METHODS: We identified 21 case-control and 8 cohort studies, including a total of 18,759 NHL cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. RESULTS: The overall relative risk (RR) of NHL for drinkers versus non-drinkers was 0.85 [95% confidence interval (CI) 0.79-0.91]. Compared with non-drinkers, the pooled RRs were 0.88 for light (≤1 drink per day), 0.87 for moderate (1 to <4 drinks per day), and 0.84 for heavy (≥4 drinks per day) alcohol drinking. There was no association for light drinkers in cohort studies, whereas for moderate and heavy drinkers, the RRs were similar in case-control (0.85 for moderate, 0.92 for heavy) and cohort (0.89 for moderate, 0.79 for heavy) studies. The inverse relation with alcohol consumption (drinkers versus non-drinkers) was similar in men (RR = 0.83) and women (RR = 0.86), but apparently stronger in studies from Asia (RR = 0.69) than other world areas (RR = 0.88). CONCLUSION: This meta-analysis provides quantitative evidence of a favourable role of alcohol drinking on NHL risk, though the lack of a biological explanation suggests caution in the interpretation of results.
Authors: Paige M Bracci; Yolanda Benavente; Jennifer J Turner; Ora Paltiel; Susan L Slager; Claire M Vajdic; Aaron D Norman; James R Cerhan; Brian C H Chiu; Nikolaus Becker; Pierluigi Cocco; Ahmet Dogan; Alexandra Nieters; Elizabeth A Holly; Eleanor V Kane; Karin E Smedby; Marc Maynadié; John J Spinelli; Eve Roman; Bengt Glimelius; Sophia S Wang; Joshua N Sampson; Lindsay M Morton; Silvia de Sanjosé Journal: J Natl Cancer Inst Monogr Date: 2014-08
Authors: V Bagnardi; M Rota; E Botteri; I Tramacere; F Islami; V Fedirko; L Scotti; M Jenab; F Turati; E Pasquali; C Pelucchi; C Galeone; R Bellocco; E Negri; G Corrao; P Boffetta; C La Vecchia Journal: Br J Cancer Date: 2014-11-25 Impact factor: 7.640