Literature DB >> 22356194

Targeting strategies for Human immunodeficiency virus: a combinatorial approach.

S K Saxena1, A Gupta, K Bhagyashree, R Saxena, N Arora, A K Banerjee, A K Tripathi, M J N Chandrasekar, N Gandhi, M P N Nair.   

Abstract

The battle between human and the Human immunodeficiency virus (HIV) is on, with both of them rapidly improving their attacking and defense strategies. Many therapeutic agents for HIV infection have been designed and developed, However there are various aspects, like novel targets against HIV, which are yet to be unfolded with a goal of designing and developing novel drug molecules against HIV. This article reviews the current status and innovative new options for antiretroviral therapy for HIV and also discusses the various mechanisms of action for each class of drugs, and the problems yet to be solved with respect to HIV as a target for improvised treatment against AIDS.
© 2012 Bentham Science Publishers

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Year:  2012        PMID: 22356194     DOI: 10.2174/1389557511209030236

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN: 1389-5575            Impact factor:   3.862


  4 in total

1.  Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef.

Authors:  Shailendra K Saxena; Gaurav Shrivastava; Sneham Tiwari; Ml Arvinda Swamy; Madhavan Pn Nair
Journal:  Future Virol       Date:  2012-06-01       Impact factor: 1.831

2.  Multi-target drugs: the trend of drug research and development.

Authors:  Jin-Jian Lu; Wei Pan; Yuan-Jia Hu; Yi-Tao Wang
Journal:  PLoS One       Date:  2012-06-29       Impact factor: 3.240

Review 3.  Interactive effects of cocaine on HIV infection: implication in HIV-associated neurocognitive disorder and neuroAIDS.

Authors:  Santosh Dahal; Sai V P Chitti; Madhavan P N Nair; Shailendra K Saxena
Journal:  Front Microbiol       Date:  2015-09-08       Impact factor: 5.640

4.  The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects.

Authors:  Mark Johnson; Roxanne C Jewell; Amanda Peppercorn; Elizabeth Gould; Jianfeng Xu; Yu Lou; Matthew Davies; Sandra Baldwin; Allan R Tenorio; Matthew Burke; Jerry Jeffrey; Brian A Johns
Journal:  Pharmacol Res Perspect       Date:  2018-06-05
  4 in total

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