Literature DB >> 22355800

The hygiene hypothesis: an explanation for the increased frequency of insulin-dependent diabetes.

Jean-François Bach1, Lucienne Chatenoud.   

Abstract

The steadily increasing frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections. Epidemiologic and animal data support this conclusion, which, however, requires confirmation by intervention trials in man. The mechanisms of the protective effect of infections on diabetes onset are diverse including competition for homeostatic factors and stimulation of regulatory T cells and of Toll-like receptors. These considerations might have interesting therapeutic applications for the prevention of the disease.

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Year:  2012        PMID： 22355800      PMCID： PMC3281594          DOI： 10.1101/cshperspect.a007799

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  59 in total

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Review 4.  Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review.

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Review 4.  Modulation of Type 1 Diabetes Risk by the Intestinal Microbiome.

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Review 5.  Risk of Type 1 Diabetes in the Offspring Born through Elective or Non-elective Caesarean Section in Comparison to Vaginal Delivery: a Meta-Analysis of Observational Studies.

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Review 7.  Regulation of inflammation by microbiota interactions with the host.

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Review 8.  The environment and the origins of islet autoimmunity and Type 1 diabetes.

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Review 9.  Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.

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Journal:  Cell       Date:  2016-04-28       Impact factor: 41.582
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