Literature DB >> 22354849

Osteocyte RANKL: new insights into the control of bone remodeling.

Jinhu Xiong1, Charles A O'Brien.   

Abstract

The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major source of RANKL driving osteoclast formation in cancellous bone. The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling.
Copyright © 2012 American Society for Bone and Mineral Research.

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Year:  2012        PMID： 22354849      PMCID： PMC3449092          DOI： 10.1002/jbmr.1547

Source DB:  PubMed          Journal:  J Bone Miner Res        ISSN： 0884-0431            Impact factor:   6.741


  74 in total

1.  Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue.

Authors:  Luis Cardoso; Brad C Herman; Olivier Verborgt; Damien Laudier; Robert J Majeska; Mitchell B Schaffler
Journal:  J Bone Miner Res       Date:  2009-04       Impact factor: 6.741

2.  Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.

Authors:  S Kousteni; T Bellido; L I Plotkin; C A O'Brien; D L Bodenner; L Han; K Han; G B DiGregorio; J A Katzenellenbogen; B S Katzenellenbogen; P K Roberson; R S Weinstein; R L Jilka; S C Manolagas
Journal:  Cell       Date:  2001-03-09       Impact factor: 41.582

3.  Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).

Authors:  W Balemans; M Ebeling; N Patel; E Van Hul; P Olson; M Dioszegi; C Lacza; W Wuyts; J Van Den Ende; P Willems; A F Paes-Alves; S Hill; M Bueno; F J Ramos; P Tacconi; F G Dikkers; C Stratakis; K Lindpaintner; B Vickery; D Foernzler; W Van Hul
Journal:  Hum Mol Genet       Date:  2001-03-01       Impact factor: 6.150

4.  A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy.

Authors:  H Kamioka; T Honjo; T Takano-Yamamoto
Journal:  Bone       Date:  2001-02       Impact factor: 4.398

5.  Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter.

Authors:  Sonja Gebhard; Takako Hattori; Eva Bauer; Britta Schlund; Michael R Bösl; Benoit de Crombrugghe; Klaus von der Mark
Journal:  Matrix Biol       Date:  2008-07-12       Impact factor: 11.583

6.  Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.

Authors:  Takashi Nakamura; Yuuki Imai; Takahiro Matsumoto; Shingo Sato; Kazusane Takeuchi; Katsuhide Igarashi; Yoshifumi Harada; Yoshiaki Azuma; Andree Krust; Yoko Yamamoto; Hiroshi Nishina; Shu Takeda; Hiroshi Takayanagi; Daniel Metzger; Jun Kanno; Kunio Takaoka; T John Martin; Pierre Chambon; Shigeaki Kato
Journal:  Cell       Date:  2007-09-07       Impact factor: 41.582

7.  Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

Authors:  Sawako Tatsumi; Kiyoaki Ishii; Norio Amizuka; Minqi Li; Toshihiro Kobayashi; Kenji Kohno; Masako Ito; Sunao Takeshita; Kyoji Ikeda
Journal:  Cell Metab       Date:  2007-06       Impact factor: 27.287

8.  Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.

Authors:  Carlo Galli; Lee A Zella; Jackie A Fretz; Qiang Fu; J Wesley Pike; Robert S Weinstein; Stavros C Manolagas; Charles A O'Brien
Journal:  Endocrinology       Date:  2007-10-11       Impact factor: 4.736

9.  Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.

Authors:  Alexander G Robling; Paul J Niziolek; Lee A Baldridge; Keith W Condon; Matthew R Allen; Imranul Alam; Sara M Mantila; Jelica Gluhak-Heinrich; Teresita M Bellido; Stephen E Harris; Charles H Turner
Journal:  J Biol Chem       Date:  2007-12-17       Impact factor: 5.157

10.  Control of bone mass and remodeling by PTH receptor signaling in osteocytes.

Authors:  Charles A O'Brien; Lilian I Plotkin; Carlo Galli; Joseph J Goellner; Arancha R Gortazar; Matthew R Allen; Alexander G Robling; Mary Bouxsein; Ernestina Schipani; Charles H Turner; Robert L Jilka; Robert S Weinstein; Stavros C Manolagas; Teresita Bellido
Journal:  PLoS One       Date:  2008-08-13       Impact factor: 3.240
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  85 in total

Review 1.  New developments in our understanding of vitamin metabolism, action and treatment.

Authors:  Sylvia Christakos; Shanshan Li; Jessica De La Cruz; Daniel D Bikle
Journal:  Metabolism       Date:  2019-06-19       Impact factor: 8.694

Review 2.  Investigating Osteocytic Perilacunar/Canalicular Remodeling.

Authors:  Cristal S Yee; Charles A Schurman; Carter R White; Tamara Alliston
Journal:  Curr Osteoporos Rep       Date:  2019-08       Impact factor: 5.096

3.  Remodeling in bone without osteocytes: billfish challenge bone structure-function paradigms.

Authors:  Ayelet Atkins; Mason N Dean; Maria Laura Habegger; Phillip J Motta; Lior Ofer; Felix Repp; Anna Shipov; Steve Weiner; John D Currey; Ron Shahar
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-20       Impact factor: 11.205

Review 4.  Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

Authors:  Marc N Wein; Marc Foretz; David E Fisher; Ramnik J Xavier; Henry M Kronenberg
Journal:  Trends Endocrinol Metab       Date:  2018-08-24       Impact factor: 12.015

Review 5.  Updates on mechanism of action and clinical efficacy of risedronate in osteoporosis.

Authors:  Ranuccio Nuti
Journal:  Clin Cases Miner Bone Metab       Date:  2014-09

6.  Association of gene polymorphisms in RANKL/RANK/OPG system with hypertension and blood pressure in Chinese women.

Authors:  P Duan; Z-M Wang; J Liu; L-N Wang; Z Yang; P Tu
Journal:  J Hum Hypertens       Date:  2015-03-26       Impact factor: 3.012

Review 7.  Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?

Authors:  R Sapir-Koren; G Livshits
Journal:  Osteoporos Int       Date:  2014-07-17       Impact factor: 4.507

8.  The enigmas of bone without osteocytes.

Authors:  Ron Shahar; Mason N Dean
Journal:  Bonekey Rep       Date:  2013-05-01

9.  METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.

Authors:  Jian Huang; Yi-Hsiang Hsu; Maxrco Brotto; David Karasik; Chenglin Mo; Eduardo Abreu; Douglas P Kiel; Lynda F Bonewald
Journal:  J Bone Miner Res       Date:  2014-07       Impact factor: 6.741

Review 10.  Acute and Stress-related Injuries of Bone and Cartilage: Pertinent Anatomy, Basic Biomechanics, and Imaging Perspective.

Authors:  Mini N Pathria; Christine B Chung; Donald L Resnick
Journal:  Radiology       Date:  2016-07       Impact factor: 11.105
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