BACKGROUND/AIMS: There have been few reports comparing pre and postoperative prevalence of Helicobacter pylori infection and gastritis in patients with gastric cancer surgery. METHODOLOGY: Seventy patients with primary gastric cancer were identified to be infected with Helicobacter pylori preoperatively and tested for Helicobacter pylori infection after subtotal gastrectomy. We analyzed changes in Helicobacter pylori infectivity and histological features of gastric mucosa. RESULTS: The overall spontaneous regression rate of Helicobacter pylori infection was 38.6% (27/70). The mean time between surgery and follow-up tests was 1.02±0.5 years. The activity and chronic inflammation scores were significantly decreased in regression group. In non-regression group, there was no significant difference in activity scores, but the chronic inflammation score was significantly increased. There were no significant changes in atrophic gastritis and intestinal metaplasia scores in either group. The grade of Helicobacter pylori infection was significantly decreased in non-regression group. CONCLUSIONS: The spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy was 38.6% (27/70), it occurred in larger scale of patients and it occurred earlier (1.02±0.5 years) than in previous studies. We suggest that further prospective study on spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy and its mechanism is needed in the future.
BACKGROUND/AIMS: There have been few reports comparing pre and postoperative prevalence of Helicobacter pylori infection and gastritis in patients with gastric cancer surgery. METHODOLOGY: Seventy patients with primary gastric cancer were identified to be infected with Helicobacter pylori preoperatively and tested for Helicobacter pylori infection after subtotal gastrectomy. We analyzed changes in Helicobacter pylori infectivity and histological features of gastric mucosa. RESULTS: The overall spontaneous regression rate of Helicobacter pylori infection was 38.6% (27/70). The mean time between surgery and follow-up tests was 1.02±0.5 years. The activity and chronic inflammation scores were significantly decreased in regression group. In non-regression group, there was no significant difference in activity scores, but the chronic inflammation score was significantly increased. There were no significant changes in atrophic gastritis and intestinal metaplasia scores in either group. The grade of Helicobacter pylori infection was significantly decreased in non-regression group. CONCLUSIONS: The spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy was 38.6% (27/70), it occurred in larger scale of patients and it occurred earlier (1.02±0.5 years) than in previous studies. We suggest that further prospective study on spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy and its mechanism is needed in the future.
Authors: Kichul Yoon; Nayoung Kim; Jaeyeon Kim; Jung Won Lee; Hye Seung Lee; Jong-Chan Lee; Hyuk Yoon; Cheol Min Shin; Young Soo Park; Sang-Hoon Ahn; Do Joong Park; Hyung Ho Kim; Yoon Jin Lee; Kyoung-Ho Lee; Young-Hoon Kim; Dong Ho Lee Journal: Gut Liver Date: 2017-03-15 Impact factor: 4.519
Authors: Luigi Basso; Gaetano Gallo; Daniele Biacchi; Maria Vittoria Carati; Giuseppe Cavallaro; Luca Esposito; Andrea Giuliani; Luciano Izzo; Paolo Izzo; Antonietta Lamazza; Andrea Polistena; Mariarita Tarallo; Alessandro Micarelli; Enrico Fiori Journal: J Clin Med Date: 2022-03-09 Impact factor: 4.241