Literature DB >> 22353220

Latest advances towards the discovery of 5-HT(7) receptor ligands.

V Pittala1, D Pittala.   

Abstract

The 5-HT(7)receptor (5-HT(7)R), characterized in 1993, is the most recently described member of the serotonin family. Since its discovery, 5-HT(7)R has been the subject of extensive research due to its widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to illustrate the literature concerning developments of the last few years (2007-2010) towards the discovery of novel and selective 5-HT(7)R ligands, agonists, antagonist and inverse agonists.

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Year:  2011        PMID： 22353220     DOI： 10.2174/138955711797655353

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  5 in total

1.  Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis.

Authors:  Yuan-Qiang Wang; Wei-Wei Lin; Nan Wu; Si-Yi Wang; Mao-Zi Chen; Zhi-Hua Lin; Xiang-Qun Xie; Zhi-Wei Feng
Journal:  Acta Pharmacol Sin       Date:  2019-02-27       Impact factor: 6.150

2.  Effects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin 7 receptor.

Authors:  Toshiyuki Ueki; Akinori Nishi; Sachiko Imamura; Hitomi Kanno; Kazushige Mizoguchi; Kyoji Sekiguchi; Yasushi Ikarashi; Yoshio Kase
Journal:  Cell Mol Neurobiol       Date:  2012-09-12       Impact factor: 5.046

3.  Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.

Authors:  Enza Lacivita; Paola De Giorgio; Daniela Patarnello; Mauro Niso; Nicola A Colabufo; Francesco Berardi; Roberto Perrone; Grzegorz Satala; Beata Duszynska; Andrzej J Bojarski; Marcello Leopoldo
Journal:  Exp Brain Res       Date:  2013-04-10       Impact factor: 1.972

4.  5-HT7 receptor activation: procognitive and antiamnesic effects.

Authors:  A Meneses; G Perez-Garcia; G Liy-Salmeron; T Ponce-López; E Lacivita; M Leopoldo
Journal:  Psychopharmacology (Berl)       Date:  2014-07-31       Impact factor: 4.530

5.  Bioisosteric matrices for ligands of serotonin receptors.

Authors:  Dawid Warszycki; Stefan Mordalski; Jakub Staroń; Andrzej J Bojarski
Journal:  ChemMedChem       Date:  2015-03-13       Impact factor: 3.466
  5 in total

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