Literature DB >> 22352853

Z-Selective copper-catalyzed asymmetric allylic alkylation with Grignard reagents.

Massimo Giannerini1, Martín Fañanás-Mastral, Ben L Feringa.   

Abstract

Allylic gem-dichlorides undergo regio- and enanantioselective (er up to 99:1) copper-catalyzed allylic alkylation with Grignard reagents affording chiral Z-vinyl chlorides. This highly versatile class of synthons can be subjected to Suzuki cross coupling affording optically active Z-alkenes and 1,3-cis,trans dienes.
© 2012 American Chemical Society

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Year:  2012        PMID： 22352853     DOI： 10.1021/ja300743t

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  4 in total

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3.  Enantio- and Diastereoselective Copper-Catalyzed Allylboration of Alkynes with Allylic gem-Dichlorides.

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  4 in total

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