Literature DB >> 22352152

Strategies for handling normality assumptions in multi-level modeling: a case study estimating trajectories of Health Utilities Index Mark 3 scores.

Julie Bernier1, Yan Feng, Keiko Asakawa.   

Abstract

BACKGROUND: With longitudinal data, lifetime health statusŏ dynamics can be estimated by modeling trajectories. Health status trajectories measured by the Health Utilities Index Mark 3 (HUI3) modeled as a function of age alone and also of age and socio-economic covariates revealed non-normal residuals and variance estimation problems. The possibility of transforming the HUI3 distribution to obtain residuals that approximate a normal distribution was investigated. DATA AND METHODS: The analysis is based on longitudinal data from the first six cycles of the National Population Health Survey (NPHS). The data pertain to 7,784 individuals, who, in 1994/1995, were aged 40 to 99, were living in private households, and had complete information on HUI3. A multilevel growth model was used to examine the hierarchical structure of NPHS data (repeated measurements nesting within respondents). The transformation of arcsine [2 x (HUI + 0.36) / (1 + 0.36)-1] was used to improve the distribution of the residuals at both levels and limit the conditional mean to the -0.36 to 1.00 interval. A model was estimated using socio-economic determinants. Analyses were performed with SAS and MLwiN.
RESULTS: After the transformation of HUI3, the model was satisfactory and allowed for inclusion of new socio-demographic and health variables in order to estimate their impact on the health-related quality of life of aging populations. Because of the complex transformation of the arcsine model, the regression coefficients were not interpreted. Instead, the estimation results were summarized graphically.

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Year:  2011        PMID: 22352152

Source DB:  PubMed          Journal:  Health Rep        ISSN: 0840-6529            Impact factor:   4.796


  2 in total

1.  Physical activity matters: associations among body mass index, physical activity, and health-related quality of life trajectories over 10 years.

Authors:  David Feeny; Rochelle Garner; Julie Bernier; Amanda Thompson; Bentson H McFarland; Nathalie Huguet; Mark S Kaplan; Nancy A Ross; Chris M Blanchard
Journal:  J Phys Act Health       Date:  2013-10-31

2.  Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment.

Authors:  Corinne Betts; Amer F Saleh; Andrey A Arzumanov; Suzan M Hammond; Caroline Godfrey; Thibault Coursindel; Michael J Gait; Matthew Ja Wood
Journal:  Mol Ther Nucleic Acids       Date:  2012-08-14       Impact factor: 10.183

  2 in total

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